scholarly journals Encountering Pharmacogenetic Test Results in the Psychiatric Clinic

2021 ◽  
pp. 070674372110588
Author(s):  
Chad A Bousman ◽  
Gouri Mukerjee ◽  
Xiaoyu Men ◽  
Ruslan Dorfman ◽  
Daniel J Müller ◽  
...  
2016 ◽  
Vol 19 (2) ◽  
pp. 215-223 ◽  
Author(s):  
Kelly E. Caudle ◽  
Henry M. Dunnenberger ◽  
Robert R. Freimuth ◽  
Josh F. Peterson ◽  
Jonathan D. Burlison ◽  
...  

2021 ◽  
Author(s):  
Jai N Patel ◽  
Danielle Boselli ◽  
James Symanowski ◽  
Stephanie Wodarski ◽  
ShRhonda Turner ◽  
...  

Aim: We evaluated the application and clinical impact of multi-gene pharmacogenetic testing in oncology palliative medicine. Patients & Methods: In a single-arm pilot trial, cancer patients with uncontrolled pain were assessed in a palliative medicine clinic at baseline and received pharmacogenetic testing. Results were used as applicable up to the final visit (day 30). Pain scores, opioid prescribing, and use of pharmacogenetic test results were collected. Results: In 75 patients, the median baseline pain score was 7/10. Of 54 evaluable at the final visit, 28 required opioid modifications and 19 had actionable genotypes, mostly CYP2D6. Pain improvement (≥2-point reduction) was higher than historical data (56 vs 30%; p < 0.001). There were no differences in pain improvement between those with and without actionable genotypes (61 vs 53%). Conclusion: Multi-gene testing identified actionable genotypes and may improve cancer pain.


2020 ◽  
Vol 21 (4) ◽  
pp. 247-256 ◽  
Author(s):  
Chloé Petit ◽  
Audrey Croisetière ◽  
Flora Chen ◽  
Isabelle Laverdière

Aim: The pharmacists are identified as one of the best positioned health professionals to lead intercollaborative efforts in tailoring medication based on pharmacogenetic information. As pharmacotherapy specialists, they can take on a prominent role in ordering and interpreting pharmacogenetic test results and then guiding optimal drug selection and dose based on those results. Participants & methods: To assess the readiness of pharmacists and trainees in the province of Quebec to assume this role, we surveyed their knowledge in (pharmaco)genetics, their confidence in their ability to use pharmacogenetics and their attitude toward the integration of this tool in clinical practice. Results: A total of 99 pharmacists (community: 67.7%, hospital: 24.2% and other: 8.1%) and 36 students volunteered in a self-administered online survey. About 50% of the questions on the participants’ knowledge are answered correctly, with a stepwise increase of right answers with hours of education in (pharmaco)genetics (51.2, 63.8 and 76.7% for <5, 5–25 and >25 h respectively; p < 0.0001). While the majority of participants believe that pharmacogenetics will gain more room in their future practice (80.7%), the overall rate of confidence in their ability to use pharmacogenetics information is low (22%) and 90.3% desire more training. Conclusion: The limited experience of pharmacists in pharmacogenetics appears to be a barrier for its integration in clinical practice.


2015 ◽  
Vol 16 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Susanne B Haga ◽  
Rachel Mills

2019 ◽  
Vol 20 (11) ◽  
pp. 781-789
Author(s):  
Leland E Hull ◽  
Catherine Chanfreau-Coffinier ◽  
Sony Tuteja ◽  
Dan Berlowitz ◽  
Lisa S Lehmann ◽  
...  

Aim: Describe the characteristics of providers ordering, patients receiving, and clinical impact of a psychotropic pharmacogenetic test on veteran care. Patients & methods: Observational cohort study linking veterans' laboratory results to electronic health record data. Changes in psychotropic medication prescribing were measured as a function of test results. Results: A total of 38 providers tested 181 veterans between 10/6/2014 and 2/1/2018. Prescriptions for medications with severe gene–drug interactions decreased; however, 11 such medications were used after testing. For 43 patients, documentation of the results was missing. Conclusion: Most prescribing decisions were congruent with test results, but in a nontrivial number of cases, prescribers appeared not to act on the results. Poor result documentation impeded the potential of results to inform clinical care.


2019 ◽  
Vol 106 (5) ◽  
pp. 942-944 ◽  
Author(s):  
Cyrine E. Haidar ◽  
Mary V. Relling ◽  
James M. Hoffman

2011 ◽  
Vol 13 (10) ◽  
pp. 887-890 ◽  
Author(s):  
Susanne B. Haga ◽  
Kensaku Kawamoto ◽  
Robert Agans ◽  
Geoffrey S. Ginsburg

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