Growth hormone releasing factor (GRF) immunoreactivity in human and rat gastrointestinal tract and pancreas.

Rabbit antisera were raised against a synthetic growth hormone releasing factor, which was originally isolated from a human pancreatic endocrine tumor (hpGRF-44). The antisera obtained showed no significant cross-reactivity with a variety of neurohormonal peptides. In addition to its occurrence in the human, but not in the rat, hypothalamus, hpGRF-44-like immunoreactivity was identified in human gastric antrum and human as well as rat pancreatic islets, using an indirect immunoperoxidase technique. Staining of serial sections and double staining revealed that in the gastric antrum the immunoreactivity was largely confined to gastrin (G) cells, whereas in pancreatic islets polypeptide (pp) cells were reactive. The physiological significance of these findings remains to be established.

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Pharmacodynamic of growth hormone secretion after injection of synthetic growth hormone releasing factor to healthy volunteers

European Journal of Pharmacology ◽

10.1016/0014-2999(90)93132-a ◽

1990 ◽

Vol 183 (2) ◽

pp. 280

Author(s):

P. Girard ◽

R. Cohen ◽

G. Sassolas ◽

J.-P. Boissel

Keyword(s):

Growth Hormone ◽

Healthy Volunteers ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Growth Hormone Releasing Factor ◽

Synthetic Growth

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Effects of synthetic growth hormone-releasing factor in women treated with gonadotrophin

Human Reproduction ◽

10.1093/oxfordjournals.humrep.a138088 ◽

1993 ◽

Vol 8 (4) ◽

pp. 525-527 ◽

Cited By ~ 9

Author(s):

Togas Tulandi ◽

Tommaso Falcone ◽

Harvey Guyda ◽

Robert Hemmings ◽

Reinhart Billiar ◽

...

Keyword(s):

Growth Hormone ◽

Growth Hormone Releasing Factor ◽

Synthetic Growth

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Effect of dopamine, bombesin and cysteamine hydrochloride on plasma growth hormone response to synthetic growth hormone-releasing factor in rats

Life Sciences ◽

10.1016/0024-3205(85)90050-5 ◽

1985 ◽

Vol 36 (15) ◽

pp. 1437-1443 ◽

Cited By ~ 16

Author(s):

Ichiji Wakabayashi ◽

Yoji Tonegawa ◽

Tamotsu Shibasaki ◽

Tetsuta Ihara ◽

Makoto Hattori ◽

...

Keyword(s):

Growth Hormone ◽

Growth Hormone Response ◽

Hormone Response ◽

Plasma Growth Hormone ◽

Growth Hormone Releasing Factor ◽

Synthetic Growth

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Effect of Synthetic Growth Hormone-Releasing Factor from a Human Pancreatic Tumor on Bovine and Caprine Growth Hormone Secretion

Nihon Chikusan Gakkaiho ◽

10.2508/chikusan.55.66 ◽

1984 ◽

Vol 55 (1) ◽

pp. 66-68

Author(s):

Koichi HODATE ◽

Tetsu JOHKE ◽

Asao KAWABATA ◽

Shinichi OHASHI ◽

Masaru SHIRAKI ◽

...

Keyword(s):

Growth Hormone ◽

Pancreatic Tumor ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Growth Hormone Releasing Factor ◽

Synthetic Growth

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The effects of intranasal insufflation of growth hormone releasing factor analogie GRF1 – 29 NH2 on growth hormone secretion in children with short stature

Acta Endocrinologica ◽

10.1530/acta.0.112s135 ◽

1986 ◽

Vol 113 (4_Suppl) ◽

pp. S135-S138 ◽

Cited By ~ 10

Author(s):

M. BORKENSTEIN

Keyword(s):

Growth Hormone ◽

Short Stature ◽

Gh Deficiency ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Normal Children ◽

Serum Growth Hormone ◽

Growth Hormone Releasing Factor ◽

Serum Gh ◽

Synthetic Growth

ABSTRACT The effects of intranasal insufflation of the synthetic growth hormone releasing factor GRF 1-29-NH2 on serum growth hormone (GH) were investigated in five healthy prepubertal children with short stature. 100 μg/kg/body weight of synthetic GRF 1-29-NH2, 500 μg in 100 μl water, were insufflated intranasally after careful cleaning of the nose. GRF 1-29-NH2 induced a prompt rise of serum GH levels with peak values at 15 minutes in all children investigated. Peak serum GH values were 28.3 ± 12.0 ng/ml (x̄ ± SD), range 17.1 - 47.6 ng/ml; Δ was 27.0 ± 12.2 ng/ml (x̄ ± SD). Serum GH levels were still significantly raised 120 minutes after the insufflation of GRF 1-29-NH2 (p < 0.05). No side effects, except for burning of the nasal mucosa in one patient, were observed. The results of this study demonstrate that intranasal insufflation of synthetic GRF 1-29-NH2 induces a prompt release of GH in otherwise normal children with short stature. Pulsatile intranasal insufflation of GRF 1-29-NH2 probably could be used for the treatment of some children with GH deficiency due to a defect at a suprapituitary level.

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