Pharmacodynamic of growth hormone secretion after injection of synthetic growth hormone releasing factor to healthy volunteers

1990 ◽  
Vol 183 (2) ◽  
pp. 280
Author(s):  
P. Girard ◽  
R. Cohen ◽  
G. Sassolas ◽  
J.-P. Boissel
Keyword(s):  
Growth Hormone ◽  
Healthy Volunteers ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Factor ◽  
Synthetic Growth

scholarly journals Effect of Synthetic Growth Hormone-Releasing Factor from a Human Pancreatic Tumor on Bovine and Caprine Growth Hormone Secretion

1984 ◽  
Vol 55 (1) ◽  
pp. 66-68
Author(s):  
Koichi HODATE ◽  
Tetsu JOHKE ◽  
Asao KAWABATA ◽  
Shinichi OHASHI ◽  
Masaru SHIRAKI ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pancreatic Tumor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Factor ◽  
Synthetic Growth

The effects of intranasal insufflation of growth hormone releasing factor analogie GRF1 – 29 NH2 on growth hormone secretion in children with short stature

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S135-S138 ◽  
Author(s):  
M. BORKENSTEIN
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Gh Deficiency ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Children ◽  
Serum Growth Hormone ◽  
Growth Hormone Releasing Factor ◽  
Serum Gh ◽  
Synthetic Growth

ABSTRACT The effects of intranasal insufflation of the synthetic growth hormone releasing factor GRF 1-29-NH2 on serum growth hormone (GH) were investigated in five healthy prepubertal children with short stature. 100 μg/kg/body weight of synthetic GRF 1-29-NH2, 500 μg in 100 μl water, were insufflated intranasally after careful cleaning of the nose. GRF 1-29-NH2 induced a prompt rise of serum GH levels with peak values at 15 minutes in all children investigated. Peak serum GH values were 28.3 ± 12.0 ng/ml (x̄ ± SD), range 17.1 - 47.6 ng/ml; Δ was 27.0 ± 12.2 ng/ml (x̄ ± SD). Serum GH levels were still significantly raised 120 minutes after the insufflation of GRF 1-29-NH2 (p < 0.05). No side effects, except for burning of the nasal mucosa in one patient, were observed. The results of this study demonstrate that intranasal insufflation of synthetic GRF 1-29-NH2 induces a prompt release of GH in otherwise normal children with short stature. Pulsatile intranasal insufflation of GRF 1-29-NH2 probably could be used for the treatment of some children with GH deficiency due to a defect at a suprapituitary level.

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