Efficacy and safety of bazedoxifene, a novel selective estrogen receptor modulator for the prevention and treatment of postmenopausal osteoporosis

2010 ◽  
Vol 26 (7) ◽  
pp. 1553-1563 ◽  
Author(s):  
Santiago Palacios
Keyword(s):  
Estrogen Receptor ◽  
Postmenopausal Osteoporosis ◽  
Selective Estrogen Receptor Modulator ◽  
Efficacy And Safety ◽  
Receptor Modulator ◽  
Prevention And Treatment

scholarly journals SERMs in the prevention and treatment of postmenopausal osteoporosis: an update

2010 ◽  
Vol 54 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Jaime Kulak Júnior ◽  
Carolina Aguiar Moreira Kulak ◽  
Hugh S. Taylor
Keyword(s):  
Estrogen Receptor ◽  
Postmenopausal Osteoporosis ◽  
Single Agent ◽  
Clinical Development ◽  
Target Tissue ◽  
New Approach ◽  
Estrogen Receptor Modulators ◽  
Receptor Modulator ◽  
Prevention And Treatment ◽  
Receptor Modulators

Selective estrogen receptor modulators (SERMs) have the ability to bind the estrogen receptor (ER) and are known to confer ER agonist or antagonist effects depending on the target tissue. A number of newer SERMs, including bazedoxifene, lasofoxifene and ospemifene, are currently under clinical development for the prevention and treatment of postmenopausal osteoporosis and for other indications. Although the possibility of developing a single agent that has all of the desired characteristics of an ideal SERM seems to be unlikely, progress in the clinical development of SERMs targeted to the ER suggests that these newer compounds may have attributes that represent an improvement relative to existing SERMs. A new approach to menopausal therapy is the tissue selective estrogen complex or the pairing of a selective estrogen receptor modulator with estrogens. Further investigation will help to clarify relative benefits/risks of novel SERMs in development within specific indications.

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