PNPLA 3I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection

SUMMARYVarious variables that might influence the rapid and sustained virological response to recombinant PEG-IFN-α-2a were explored in Iraqi HCV-infected patients with haemoglobinopathy. Forty-three patients were evaluated for the relationship between rapid virological response (RVR), IL-28B polymorphism, viral load, liver enzyme levels, blood group, ultrasound findings, or HCV genotype and the sustained virological response (SVR) achievement. The overall RVR was 55·81% while the overall SVR was 53·49%. SVR in patients that achieved RVR was 82·61% (P = 0·0004). A significant association was found between initial alanine transaminase levels and viral load with SVR achievement (P = 0·025) and (P = 0·004), respectively. Thirty-two (74%) out of 43 of our samples were host genotyped at the IL-28B locus as CC, a significant association was found between CC group and SVR achievement (P = 0·04). Of our samples, 23/43 (53%) were typed as HCV genotype 4, 10/43 (23%) as genotype 1, 9/43 (20·9%) as genotype 3 and 1/43 (2·3%) as genotype 2. A significant association was found between genotype 3 and SVR achievement (P = 0·006). Multivariate analysis showed that only RVR achievement independently associated with SVR in the Iraqi population (P = 0·00). These results can be used to classify the patients requiring the more expensive new direct-acting antiviral drugs.

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236 TWELVE-WEEK COURSE OF PIFN-α-2A/RIBAVIRIN IS AN OPTIMIZED REGIMEN FOR TREATMENT OF HCV GENOTYPE 2 BUT NOT GENOTYPE 3 NON-CIRRHOTIC PATIENTS WITH RVR

Journal of Hepatology ◽

10.1016/s0168-8278(10)60238-3 ◽

2010 ◽

Vol 52 ◽

pp. S99-S100

Author(s):

L.E. Adinolfi ◽

R. Zampino ◽

B. Guerrera ◽

L. Restivo ◽

L. Rinaldi ◽

...

Keyword(s):

Genotype 3 ◽

Hcv Genotype ◽

Genotype 2 ◽

Cirrhotic Patients ◽

Hcv Genotype 2

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Histological findings and interferon treatment outcomes in patients with normal ALT levels and high viral load of HCV genotype 2

Kanzo ◽

10.2957/kanzo.48.581 ◽

2007 ◽

Vol 48 (12) ◽

pp. 581-588

Author(s):

Ayako Urabe ◽

Shiomi Aimitsu ◽

Yasuyuki Aisaka ◽

Hiroshi Kohno ◽

Hiroiku Kawakami ◽

...

Keyword(s):

Viral Load ◽

Treatment Outcomes ◽

High Viral Load ◽

Interferon Treatment ◽

Histological Findings ◽

Hcv Genotype ◽

Genotype 2 ◽

Hcv Genotype 2 ◽

Normal Alt

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Faculty Opinions recommendation of Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718431369.793495957 ◽

2014 ◽

Author(s):

Philip Rosenthal

Keyword(s):

Hcv Genotype ◽

Relapse Risk ◽

Inosine Triphosphate Pyrophosphatase ◽

Genotype 2 ◽

Hcv Genotype 2

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Faculty Opinions recommendation of Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.722006088.793500951 ◽

2014 ◽

Author(s):

Philip Rosenthal

Keyword(s):

Duration Of Treatment ◽

Hcv Genotype ◽

Genotype 2 ◽

Hcv Genotype 2 ◽

Peginterferon And Ribavirin

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THE IMPORTANCE OF ANTI-HCV SCREENING IN PATIENTS OF LARGE MULTIFIELD HOSPITALS

Molecular Diagnostics and Biosafety – 2020. Russian national scientific and practical conference with international participation (October, 6–8, 2020): Conference Proceedings ◽

10.36233/978-5-9900432-9-9-49 ◽

2020 ◽

Author(s):

E.N. Kudrjavtseva ◽

◽

M.I. Korabelnikova ◽

T.A. Semenenko ◽

Ya.V. Panasyuk ◽

...

Keyword(s):

Men And Women ◽

Hcv Genotype ◽

Genotype 2 ◽

Hcv Genotype 2 ◽

Hcv Screening ◽

Subtype 1B

In the studied cohort, HCV subtypes 1b and 3a prevailed — 47,7% and 38,9%, respectively HCV genotype 2 was detected in 7,2% of cases and HCV subtype 1a — in 5,8% of cases. HCV genotype was not determined in 0,4% of patients. Difference between a frequency of detection of subtypes 1b and 3a of HCV in men and women were recorded. Subtype 3a HCV was determined in men in 44,8% of cases, and in women — in 31,7% of cases (p < 0.01). HCV subtype 1b in women was determined with a higher frequency (55,0%, р < 0, 01), than in men (41,8%).

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