scholarly journals Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies

2009 ◽  
Vol 8 (1) ◽  
Author(s):  
Maryline Bonnet ◽  
Ingrid van den Broek ◽  
Michel van Herp ◽  
Pedro Pablo Palma Urrutia ◽  
Chantal van Overmeir ◽  
...  
2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Dieudonné Makaba Mvumbi ◽  
Jean-Marie Kayembe ◽  
Hippolyte Situakibanza ◽  
Thierry L. Bobanga ◽  
Célestin N. Nsibu ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Helen Kuokuo Kimbi ◽  
Mesame Ntoko ◽  
Nelson N. Ntonifor ◽  
Emmaculate Lum ◽  
Anna L. Njunda ◽  
...  

Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess thein vivoefficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P<0.05) on all days of followup. The drug combination did not give rise to any serious side effects.


2008 ◽  
Vol 13 (11) ◽  
pp. 1384-1391 ◽  
Author(s):  
Alisa P. Alker ◽  
Walter M. Kazadi ◽  
Albert K. Kutelemeni ◽  
Peter B. Bloland ◽  
Antoinette K. Tshefu ◽  
...  

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