scholarly journals Evaluation of heterogeneity dose distributions for Stereotactic Radiotherapy (SRT): comparison of commercially available Monte Carlo dose calculation with other algorithms

2012 ◽  
Vol 7 (1) ◽  
pp. 20 ◽  
Author(s):  
Wataru Takahashi ◽  
Hideomi Yamashita ◽  
Naoya Saotome ◽  
Yoshio Iwai ◽  
Akira Sakumi ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Stereotactic Radiotherapy ◽  
Dose Calculation ◽  
Dose Distributions ◽  
Monte Carlo Dose Calculation

scholarly journals Verification of a Monte Carlo dose calculation engine in proton minibeam radiotherapy in a passive scattering beamline for preclinical trials

2020 ◽  
Vol 93 (1107) ◽  
pp. 20190578 ◽  
Author(s):  
Consuelo Guardiola ◽  
Ludovic De Marzi ◽  
Yolanda Prezado
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Dose Calculation ◽  
Ct Images ◽  
Computational Time ◽  
Dose Distributions ◽  
Starting Point ◽  
Preclinical Trials ◽  
Monte Carlo Dose Calculation

Objectives: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the benefits of proton therapy with the remarkable normal tissue preservation observed with the use of submillimetric spatially fractionated beams. This promising technique has been implemented at the Institut Curie-Proton therapy centre (ICPO) using a first prototype of a multislit collimator. The purpose of this work was to develop a Monte Carlo-based dose calculation engine to reliably guide preclinical studies at ICPO. Methods: The whole “Y1”-passive beamline at the ICPO, including pMBRT implementation, was modelled using the Monte Carlo GATE v. 7.0 code. A clinically relevant proton energy (100 MeV) was used as starting point. Minibeam generation by means of the brass collimator used in the first experiments was modelled. A virtual source was modelled at the exit of the beamline nozzle and outcomes were compared with dosimetric measurements performed with EBT3 gafchromic films and a diamond detector in water. Dose distributions were recorded in a water phantom and in rat CT images (7-week-old male Fischer rats). Results: The dose calculation engine was benchmarked against experimental data and was then used to assess dose distributions in CT images of a rat, resulting from different irradiation configurations used in several experiments. It reduced computational time by an order of magnitude. This allows us to speed up simulations for in vivo trials, where we obtained peak-to-valley dose ratios of 1.20 ± 0.05 and 6.1 ± 0.2 for proton minibeam irradiations targeting the tumour and crossing the rat head. Tumour eradication was observed in the 67 and 22% of the animals treated respectively. Conclusion: A Monte Carlo dose calculation engine for pMBRT implementation with mechanical collimation has been developed. This tool can be used to guide and interpret the results of in vivo trials. Advances in knowledge: This is the first Monte Carlo dose engine for pMBRT that is being used to guide preclinical trials in a clinical proton therapy centre.

STEREOTACTIC RADIOTHERAPY FOR LUNG TUMOURS: TREATMENT PRESCRIPTION USING MONTE CARLO DOSE CALCULATION

2009 ◽  
Vol 92 ◽  
pp. S116
Author(s):  
R. Bolt ◽  
A. Van Der Schaaf ◽  
M. Hollander ◽  
J. Widder ◽  
A. van't Veld
Keyword(s):  
Monte Carlo ◽  
Stereotactic Radiotherapy ◽  
Dose Calculation ◽  
Lung Tumours ◽  
Monte Carlo Dose Calculation

Accurate characterization of metal implants and human materials using novel proton counting detector for Monte Carlo dose calculation in proton therapy

2021 ◽  
Author(s):  
Serdar Charyyev ◽  
Chih-Wei Chang ◽  
Joseph M. Harms ◽  
Cristina Oancea ◽  
Tim Yoon ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Dose Calculation ◽  
Metal Implants ◽  
Monte Carlo Dose Calculation

Comparison of the Batho, ETAR and Monte Carlo dose calculation methods in CT based patient models

2001 ◽  
Vol 28 (4) ◽  
pp. 582-589 ◽  
Author(s):  
F. C. P. du Plessis ◽  
C. A. Willemse ◽  
M. G. Lötter ◽  
L. Goedhals
Keyword(s):  
Monte Carlo ◽  
Dose Calculation ◽  
Calculation Methods ◽  
Monte Carlo Dose Calculation

scholarly journals Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Naonori Hu ◽  
Hiroki Tanaka ◽  
Ryo Kakino ◽  
Syuushi Yoshikawa ◽  
Mamoru Miyao ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Dose Calculation ◽  
Planning System ◽  
Treatment Planning System ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Monte Carlo Dose Calculation

AbstractBoron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.

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