scholarly journals Food allergy and anaphylaxis – 2054. Easy-to-use severity grading system for treatment of symptoms induced by oral food challenge

2013 ◽  
Vol 6 ◽  
pp. P137 ◽  
Author(s):  
Noriyuki Yanagida ◽  
Yuu Okada ◽  
Hasegawa Yukiko ◽  
Taro Miura ◽  
Ishida Wako ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Grading System ◽  
Severity Grading

scholarly journals Oral Food Challenge and Food Allergy Quality of Life in Caregivers of Children with Food Allergy

2015 ◽  
Vol 3 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Timothy J. Franxman ◽  
Laura Howe ◽  
Esther Teich ◽  
Matthew J. Greenhawt
Keyword(s):  
Quality Of Life ◽  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

scholarly journals Detection of Salivary Tryptase Levels in Children following Oral Food Challenges

2021 ◽  
pp. 1-4
Author(s):  
Wouter W. de Weger ◽  
Vibeke M. Bruinenberg ◽  
Evelien M. van der Lek ◽  
Jeroen H. Gerrits ◽  
Lidy van Lente ◽  
...  
Keyword(s):  
Food Allergy ◽  
Limit Of Detection ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Potential Association ◽  
The Mean ◽  
Food Challenges ◽  
Assay Precision ◽  
Objective Marker ◽  
Time Point

<b><i>Background:</i></b> Oral food challenge (OFC) is commonly used to diagnose food allergy. This test is time and resource intensive, and conclusions are not always unequivocal as this relies on the interpretation of symptoms. Therefore, an objective marker would improve the accuracy of the diagnostic workup of food allergy. <b><i>Objectives:</i></b> The aim of this study was to investigate whether tryptase can be detected in saliva of children following OFC. <b><i>Method:</i></b> Children from 3 to 18 years of age were eligible for inclusion if an OFC for peanut or tree nut had been recommended. Saliva samples were collected prior to the first dose and 5, 10, and 15 min following the last administered dose during OFC. Assay precision, spike-and-recovery, and assessment of lower limit of detection of the tryptase immunoassay were examined before analysis of tryptase in saliva was performed. <b><i>Results:</i></b> A total of 30 children were included (median age 8 years, 63.3% male, 53.3% positive OFC outcome). Tryptase was detected in saliva samples. The mean of the change in baseline tryptase value to each saliva collecting time point was significantly different in patients with a positive OFC outcome compared to a negative outcome (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> This study showed that tryptase can be detected in saliva of children following OFC. Increased levels of tryptase compared to baseline were found if the OFC outcome was positive, suggesting that measuring tryptase in saliva may be useful in the diagnosis of food allergy. Further research is needed to evaluate the potential association between tryptase levels and symptoms.

Caregiver perceptions of when to offer an oral food challenge for children with food allergy

2019 ◽  
Vol 122 (6) ◽  
pp. 660-661
Author(s):  
Monica T. Kraft ◽  
Rebecca Scherzer ◽  
Elizabeth A. Erwin ◽  
Irene Mikhail
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

Oral Food Challenge: Experience in a Brazilian Food Allergy Outpatient Terciary Service

2013 ◽  
Vol 131 (2) ◽  
pp. AB83
Author(s):  
Camila Pereira ◽  
Leila Borges ◽  
Renata R. Cocco ◽  
Lucila Camargo ◽  
Marcia Mallozi ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

Organ-specific symptoms during oral food challenge in children with food allergy

2012 ◽  
Vol 130 (2) ◽  
pp. 549-551 ◽  
Author(s):  
Birgit Ahrens ◽  
Bodo Niggemann ◽  
Ulrich Wahn ◽  
Kirsten Beyer
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Organ Specific ◽  
Specific Symptoms

scholarly journals The effectiveness of skin prick test in diagnosing severe paediatric food allergy: A systematic review

2021 ◽  
Author(s):  
Daniel Zhou ◽  
Evelyn Fleming ◽  
Colin Macdougall
Keyword(s):  
Systematic Review ◽  
Food Allergy ◽  
Skin Prick Test ◽  
Predictive Value ◽  
Food Challenge ◽  
Paediatric Population ◽  
Oral Food Challenge ◽  
Prick Test ◽  
Parents And Children ◽  
Skin Prick Tests

There is an increasing incidence of food allergy identified globally in the paediatric population. Diagnosis of suspected cases by oral food challenge (OFC) is time-consuming and often linked to anxiety in parents and children. There is also a risk of triggering an anaphylaxis reaction between 2.4%-34.1% of challenges triggering anaphylaxis. To reduce the number of OFC carried out in allergy-suspected children, the use of skin prick tests (SPT) is a simpler and less expensive method of diagnosis. Although the predictive value of the SPT remains unclear, hence there is a requirement for further studies on the predictive value of the SPT to provide increased clarity of the essential parameters.

scholarly journals Oral food challenge in IgE mediated food allergy in eastern Mediterranean children

2021 ◽  
Vol 49 (3) ◽  
pp. 185-192
Author(s):  
Hilal Unsal ◽  
Gokce Ozyilmaz Bozat ◽  
Melike Ocak ◽  
Aysegul Akarsu ◽  
Umit Murat Sahiner ◽  
...  
Keyword(s):  
Food Allergy ◽  
Preschool Children ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Tree Nuts ◽  
Increased Risk ◽  
Hen’S Egg ◽  
Ige Mediated

Background: The oral food challenge (OFC) in IgE mediated food allergy causes anxiety both in parents and in patients due to its inherent risks.Objective: Documentation of the rate, spectrum, and predictors of positive reactions is instructive.Methods: Children, who underwent OFC between January 1, 2017 and December 31, 2019 were analyzed.Results: A total of 1361 OFCs in 613 cases were reviewed. Most of them were performed in preschool children (≤2 years 50%) and 55% of them had more than one OFC. Mainly consid-ered food groups were cow’s milk (31.8%), hen’s egg (28.5%), tree nuts (20%), legumes (7%), seeds (4.9%), and wheat (2.7%). The overall OFC positivity was 9.6%, whereas 6.7% with cow’s milk, 4.9% with hen’s egg, 16.1% with tree nuts, 21.6% with wheat, and 32.8% with seeds. The severity scoring revealed grade I (24.4%), II (45.8%), and III (29.7%) reactions. Fifty (38%) cases required epinephrine and four cases required hospitalization. OFCs with sesame seeds (odds ratio [OR]: 7.747, [confidence interval (CI) 95%: 4.03–14.90]), wheat (OR: 3.80, [CI: 1.64–8.84]), and tree nuts (OR: 2.78, [CI: 1.83–4.23]) predicted a positive OFC while a concomitant asthma (OR: 3.61 [CI: 1.27–10.28]) was more likely to elicit anaphylaxis.Conclusion: In OFC practice, priority is given to basic nutritional sources and the most frequent food allergens, where preschool children with multiple sensitizations are the primary subjects. Increased risks of positive reactions with sesame, tree nut, and wheat and increased risk of anaphylaxis with concomitant asthma should be considered while performing OFC.

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