Using single-subject methodology to investigate psychiatric treatments in                 systemic lupus erythematosus

This study presents an experimental Single Case-Single Subject ABA design of a 17-year-old female patient suffering from Systemic Lupus Erythematosus (SLE) and Pulmonary Tuberculosis (TB) who experience adjustment disorders. The purpose of this study is to reduce adjustment disorders in the patient with SLE and pulmonary TB by using art therapy. The assessment methods are observation, interviews, and psychological testing tools. Data analysis was carried out using the qualitatively and quantitatively. Quantitative analysis is performed using visual inspection by looking at the comparison of Depression Anxiety Stress Scale (DASS) scores. Initial measurements using DASS showed a level of depression with a score of 26 (severe), anxiety score at 23 (very severe), and stress score at 19 (moderate). Art therapy is given as a therapeutic intervention for the patient. After the therapy was given, there was a decrease in the DASS score with a depression score to 20 (moderate), anxiety score at 19 (severe), and stress score at 17 (mild). The patient also felt moreable to express and control emotions more precisely. These results indicate that art therapy is one of the interventions that can overcome psychological problems in the patient with adjustment disorders.

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Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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