Pharmacological interventions for treatment-resistant depression in adults: a Cochrane Review

2021 ◽  
Vol 28 (1) ◽  
pp. 2-3
Author(s):  
Philippa Davies ◽  
Sharea Ijaz ◽  
Catherine J. Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Pharmacological Interventions ◽  
Resistant Depression

Treatment Resistant Depression: A Clinical Perspective*

1988 ◽  
Vol 33 (9) ◽  
pp. 788-792 ◽  
Author(s):  
G. William Macewan ◽  
Ronald A. Remick
Keyword(s):  
Bipolar Disorder ◽  
Treatment Resistance ◽  
Treatment Resistant Depression ◽  
Clinical Perspective ◽  
Recurrent Depression ◽  
Treatment Resistant ◽  
Pharmacological Interventions ◽  
Axis Ii ◽  
Symptom Remission ◽  
Resistant Depression

One hundred and fourteen patients with a diagnosis of “treatment resistant depression” (TRD) were assessed and treated at a Mood Disorders Clinic. Diagnostically, 52 (45.6%) subjects met criteria for bipolar disorder, 49 (42.9%) for recurrent depression, and 13 (11.4%) patients did not fulfill diagnostic criteria for affective disorder which explained their treatment resistance. With appropriate, individualized treatment, 59 of 98 (60.2%) patients had complete symptom remission based on clinical and psychometric ratings (initial Ham-D 26.7, final Ham-D 5.9). Eighteen of 98 patients had partial remission (final Ham-D 15.9) with vigorous pharmacological interventions, and 8 subjects exhibited “absolute” TRD (final Ham-D 23.4). The results suggest the value of specialized mood disorder services. The partial and absolute TRD's were more likely to be older, received more Axis II diagnoses, and had previous histories of drug or alcohol abuse.

scholarly journals Psychological therapies for treatment-resistant depression in adults: a Cochrane Review

2020 ◽  
Vol 26 (5) ◽  
pp. 254-254
Author(s):  
Sharea Ijaz ◽  
Philippa Davies ◽  
Catherine J. Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Psychological Therapies ◽  
Resistant Depression

scholarly journals Pharmacological interventions for treatment-resistant depression in adults

2013 ◽  
Author(s):  
Catherine J Williams ◽  
Michelle Taylor ◽  
David Kessler ◽  
Glyn Lewis ◽  
Nicola Wiles
Keyword(s):  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Pharmacological Interventions ◽  
Resistant Depression

Treatment-resistant depression: therapeutic options when first-line treatments fail

2021 ◽  
Vol 28 (1) ◽  
pp. 4-8
Author(s):  
Chloe Wigg ◽  
Sara Costi
Keyword(s):  
Antidepressant Treatment ◽  
Small Body ◽  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Long Term Effects ◽  
Treatment Resistant ◽  
Short Term ◽  
Augmentation Strategies ◽  
Resistant Depression

SUMMARYThe Cochrane review by Davies et al aimed to address the lack of clarity on the risks and benefits of switching and augmentation strategies in the pharmacological treatment of treatment-resistant depression in adults who did not respond (or partially responded) to at least 4 weeks of antidepressant treatment at a recommended dose. This commentary assesses their review and their conclusion that augmenting the current antidepressant with mianserin or with an antipsychotic improves depressive symptoms over the short-term (8 to 12 weeks). Their results need to be treated with caution owing to the small body of evidence and individual comparisons supported by one, two or three studies, the limited evidence on long-term effects and the significant gaps in the literature (e.g. a lack of studies assessing dose increases).

scholarly journals Pharmacological interventions for treatment-resistant depression in adults

2019 ◽  
Author(s):  
Philippa Davies ◽  
Sharea Ijaz ◽  
Catherine J Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Pharmacological Interventions ◽  
Resistant Depression
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