Metabolic Response to Electrical Stimulation in Separated Portions of Human Cerebral Tissues

1952 ◽  
Vol 98 (411) ◽  
pp. 265-272 ◽  
Author(s):  
H. McIlwain ◽  
P. J. W. Ayres ◽  
Olga Forda
Keyword(s):  
Electrical Stimulation ◽  
Chemical Analysis ◽  
Metabolic Response ◽  
Venous Blood ◽  
Blood Stream ◽  
Small Areas ◽  
Flow Information ◽  
The Brain ◽  
Stimulation Of

Electrical stimulation of different areas of the human brain has hitherto been confined to experiments with the brain in situ, in living subjects. It has been carried out while the brain received its blood supply from normal sources. By chemical analysis of the arterial and venous blood and measurement of its rate of flow, information has been obtained on how metabolic changes in the brain vary with changes in its activity. However, these conditions can give information only about gross biochemical changes associated with stimulation; they are cumbersome, and would not indicate abnormal reactions in small areas. Also, they detect differences only in substances which are actively exchanged with the blood stream.

Effect of diencephalic stimuli on 17-hydroxycorticosteroid secretion in unanesthetized dogs

1960 ◽  
Vol 198 (6) ◽  
pp. 1312-1314 ◽  
Author(s):  
Tatuzi Suzuki ◽  
Elijah B. Romanoff ◽  
Werner P. Koella ◽  
Charles K. Levy
Keyword(s):  
Electrical Stimulation ◽  
Brain Stem ◽  
Marked Decrease ◽  
Venous Blood ◽  
Secretion Rate ◽  
Hypothalamic Area ◽  
The Brain ◽  
Stimulation Of

In unanesthetized dogs, adrenal venous blood was collected and its plasma content of 17-hydroxycorticosteroids (17-OHCS) estimated. Electrodes were implanted in the brain stem and electrical stimulation was performed. The location of the electrode tips was verified histologically. After stimulation of the lower posterior hypothalamic area, as well as the lower thalamic area, the adrenal 17-OHCS secretion rate increased markedly. When the upper posterior hypothalamic area, or the area preoptica was stimulated, the slight increase in 17-OHCS secretion rate first observed was followed by a marked decrease below the prestimulation level. Stimulation of the capsula interna produced no response in adrenal cortical secretion.

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