Trop-2 as a therapeutic target for the antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132), in patients (pts) with previously treated metastatic small-cell lung cancer (mSCLC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 8559-8559 ◽  
Author(s):  
Alexander Starodub ◽  
D. Ross Camidge ◽  
Ronald J. Scheff ◽  
Sajeve Samuel Thomas ◽  
Michael J. Guarino ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Therapeutic Target ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Previously Treated ◽  
Antibody Drug

scholarly journals A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

2021 ◽  
Vol 2 (7) ◽  
pp. 100344
Author(s):  
Swetha Raman ◽  
Samantha N. Buongervino ◽  
Maria V. Lane ◽  
Doncho V. Zhelev ◽  
Zhongyu Zhu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Conformational Epitope ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals An antibody‐drug conjugate targeting a GSTA glycosite‐signature epitope of MUC1 expressed by non‐small cell lung cancer

2020 ◽  
Vol 9 (24) ◽  
pp. 9529-9540
Author(s):  
Deng Pan ◽  
Yubo Tang ◽  
Jiao Tong ◽  
Chengmei Xie ◽  
Jiaxi Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I–inhibiting Antibody–Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan

2017 ◽  
Vol 23 (19) ◽  
pp. 5711-5719 ◽  
Author(s):  
Jhanelle E. Gray ◽  
Rebecca S. Heist ◽  
Alexander N. Starodub ◽  
D. Ross Camidge ◽  
Ebenezer A. Kio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Topoisomerase I ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug
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