Transgenic Animals for Preclinical Drug Development

2005 ◽  
pp. 67-98
Author(s):  
Li-Na Wei
Keyword(s):  
Drug Development ◽  
Transgenic Animals ◽  
Preclinical Drug Development

scholarly journals Characterization and applications of chimeric mice with humanized livers for preclinical drug development

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Chise Tateno ◽  
Yuha Kojima
Keyword(s):  
Liver Function ◽  
Drug Development ◽  
Mass Production ◽  
Human Hepatocytes ◽  
In Vitro Studies ◽  
New Drugs ◽  
Pharmaceutical Companies ◽  
Chimeric Mice ◽  
Preclinical Drug Development

AbstractWe have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for clients weekly for in vitro studies. In this review, we summarize the existing characterizations of PXB-mice and PXB-cells and their present and future applications.

PRECLINICAL DRUG DEVELOPMENT PARADIGMS FOR CHEMOPREVENTIVES

1998 ◽  
Vol 12 (5) ◽  
pp. 943-961 ◽  
Author(s):  
Vernon E. Steele ◽  
Charles W. Boone ◽  
Ronald A. Lubet ◽  
James A. Crowell ◽  
Cathy A. Holmes ◽  
...  
Keyword(s):  
Drug Development ◽  
Preclinical Drug Development

Amorphous Solid Dispersions: Utilization and Challenges in Preclinical Drug Development within AstraZeneca

2021 ◽  
pp. 121387
Author(s):  
Akosua B. Anane-Adjei ◽  
Esther Jacobs ◽  
Samuel C. Nash ◽  
Sean Askin ◽  
Ramesh Soundararajan ◽  
...  
Keyword(s):  
Drug Development ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Preclinical Drug Development

Preclinical Drug Development Planning

2008 ◽  
pp. 1-63 ◽  
Author(s):  
Nirmala Bhogal ◽  
Robert Combes ◽  
Michael Balls
Keyword(s):  
Drug Development ◽  
Development Planning ◽  
Preclinical Drug Development
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