Effect of Red Blood Cell Aggregation on in Vitro Blood Rheology

2011 ◽  
pp. 133-154
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Rheology ◽  
Cell Aggregation ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

Lysophosphatidic acid induced red blood cell aggregation in vitro

2012 ◽  
Vol 87 ◽  
pp. 89-95 ◽  
Author(s):  
Lars Kaestner ◽  
Patrick Steffen ◽  
Duc Bach Nguyen ◽  
Jue Wang ◽  
Lisa Wagner-Britz ◽  
...  
Keyword(s):  
Blood Cell ◽  
Lysophosphatidic Acid ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules

2002 ◽  
Vol 283 (5) ◽  
pp. H1985-H1996 ◽  
Author(s):  
Jeffrey J. Bishop ◽  
Aleksander S. Popel ◽  
Marcos Intaglietta ◽  
Paul C. Johnson
Keyword(s):  
Shear Rate ◽  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Cell Aggregation ◽  
Radial Position ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

Previous in vitro studies of blood flow in small glass tubes have shown that red blood cells exhibit significant erratic deviations in the radial position in the laminar flow regime. The purpose of the present study was to assess the magnitude of this variability and that of velocity in vivo and the effect of red blood cell aggregation and shear rate upon them. With the use of a gated image intensifier and fluorescently labeled red blood cells in tracer quantities, we obtained multiple measurements of red blood cell radial and longitudinal positions at time intervals as short as 5 ms within single venous microvessels (diameter range 45–75 μm) of the rat spinotrapezius muscle. For nonaggregating red blood cells in the velocity range of 0.3–14 mm/s, the mean coefficient of variation of velocity was 16.9 ± 10.5% and the SD of the radial position was 1.98 ± 0.98 μm. Both quantities were inversely related to shear rate, and the former was significantly lowered on induction of red blood cell aggregation by the addition of Dextran 500 to the blood. The shear-induced random movements observed in this study may increase the radial transport of particles and solutes within the bloodstream by orders of magnitude.

In vitro effect of clinical propofol concentrations on red blood cell aggregation and deformability

2012 ◽  
Vol 51 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Yun Hee Kim ◽  
Hye Gyo Chung ◽  
Soohyun A. Myung ◽  
Jee hyun Rha ◽  
Sung Yang ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Red Blood Cell Aggregation ◽  
Vitro Effect ◽  
Blood Cell Aggregation
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