24 GASTROINTESTINAL (GI) MOTILITY, DUODENOGASTRIC REFLUX (DGR) AND GASTRIC EMPTYING (GE) IN CHILDREN WITH CHRONIC VOMITING

Duodenogastric reflux, gastric emptying, and gastric secretion were measured simultaneously by a double-marker technique after instillation of a liquid lipid meal (300 ml Intralipid) or a protein meal (300 ml Bactopeptone) in five trained mongrel dogs. A lipid meal was emptied slower and elicited less volume secretion than a protein meal. Duodenogastric reflux rate and intragastric accumulation of duodenal contents were similar with both meals. Intravenous infusion of atropine slowed gastric emptying and inhibited gastric volume secretion only in the case of protein meal. Atropine increased duodenogastric reflux rate and gastric accumulation of duodenal contents with both protein and lipid meals. The percentage of duodenal contents inside the stomach increased continuously during gastric emptying; it did not exceed 20% with both meals given alone and 40% with both meals given together with atropine. It is concluded that duodenogastric reflux and gastric accumulation of duodenal contents are common phenomena during gastric digestion of a meal. The degree of such accumulation does not depend on the type of meal. Intragastric accumulation of duodenal contents is increased when duodenogastric reflux rate is stimulated and when gastric emptying rate is inhibited simultaneously.

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Simultaneous measurement of antroduodenal motility, gastric emptying, and duodenogastric reflux in man.

Gut ◽

10.1136/gut.20.11.963 ◽

1979 ◽

Vol 20 (11) ◽

pp. 963-970 ◽

Cited By ~ 50

Author(s):

W D Rees ◽

V L Go ◽

J R Malagelada

Keyword(s):

Gastric Emptying ◽

Simultaneous Measurement ◽

Duodenogastric Reflux ◽

Antroduodenal Motility

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Effect of a Transpyloric Tube on Gastric Emptying and Duodenogastric Reflux in the Dog

Digestion ◽

10.1159/000198983 ◽

1983 ◽

Vol 28 (3) ◽

pp. 176-180 ◽

Cited By ~ 2

Author(s):

Stefan A. Müller-Lissner ◽

Gotthard Schattenmann ◽

Rüdiger Siewert ◽

André L. Blum

Keyword(s):

Gastric Emptying ◽

Duodenogastric Reflux

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The Roles of Motilin and Ghrelin in Gastrointestinal Motility

International Journal of Peptides ◽

10.1155/2010/820794 ◽

2010 ◽

Vol 2010 ◽

pp. 1-6 ◽

Cited By ~ 37

Author(s):

Tetsuro Ohno ◽

Erito Mochiki ◽

Hiroyuki Kuwano

Keyword(s):

Gastric Emptying ◽

Gastrointestinal Motility ◽

Human Subjects ◽

Motor Pattern ◽

Physiological Role ◽

Gi Tract ◽

Peptide Family ◽

Endogenous Release ◽

Interdigestive Migrating Contractions ◽

Gi Motility

In structure, ghrelin resembles motilin. The two peptides are considered to be members of the motilin-ghrelin peptide family. Motilin is considered to be an endocrine regulator of the interdigestive migrating contractions, the fasted motor pattern in the gastrointestinal (GI) tract. It has been reported that ghrelin stimulates GI motility. The gastrokinetic capacity of ghrelin has been well documented in the rodent. However, there have been few positive reports of the gastrokinetic capacity of ghrelin in dogs. Some reports with human subjects have shown that an i.v. ghrelin injection accelerated gastric emptying of a meal and improved meal-related symptoms. These results suggest that ghrelin has potential as a prokinetic. However, it seems unlikely that plasma ghrelin would play a physiological role in these digestive physiological events and stimulate gastric emptying, as these outcomes would appear to be in contradiction with the suppression of the endogenous release of ghrelin after eating. The physiological roles of ghrelin need to be clarified.

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Gastric emptying and postprandial duodenogastric reflux in pylorectomized dogs

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1982.242.1.g9 ◽

1982 ◽

Vol 242 (1) ◽

pp. G9-G14

Author(s):

S. A. Muller-Lissner ◽

A. Sonnenberg ◽

G. Schattenmann ◽

A. Hollinger ◽

J. R. Siewert ◽

...

Keyword(s):

Gastric Emptying ◽

Test Meal ◽

Duodenogastric Reflux ◽

Gastric Emptying Rate

A two-marker technique was used to determine gastric emptying rate and postprandial duodenogastric reflux rate without transpyloric intubation. The fractional gastric emptying rate in five dogs with normal pylorus was 3.0 +/- 0.3 (SE) X 10(-2)/min. In three dogs with circular pylorectomy, it was 5.8 +/- 0.8 X 10(-2)/min (P less than 0.01). The duodenogastric reflux rates were 0.72 +/- 0.23 (SE) ml/min and 3.21 +/- 0.97 ml/min. (P less than 0.05). The percentage of the test meal that by to-and-fro movements across the pylorus was emptied more than once was 2.3 +/- 1.0 (SE) in normal dogs and 15.5 +/- 2.4 after pylorectomy (P less than 0.005). Because the higher emptying rate was accompanied by more to-and-fro movements, the amount of the meal remaining in the stomach, and thus net gastric emptying, was similar in both groups. It is concluded that pylorectomy increases both reflux rate and emptying rate. This effect on emptying can only be detected by a method that includes the measurement of to-and-fro movements across the pylorus. The pylorus thus appears to prevent postprandial duodenogastric reflux and to slow gastric emptying.

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