scholarly journals Formulation and in vitro, in vivo evaluation of extended- release matrix tablet of Zidovudine: Influence of combination of hydrophilic and hydrophobic matrix formers

2006 ◽  
Vol 7 (1) ◽  
pp. E1-E9 ◽  
Author(s):  
Atul Kuksal ◽  
Ashok K. Tiwary ◽  
Narendra K. Jain ◽  
Subheet Jain
Keyword(s):  
Extended Release ◽  
Matrix Tablet ◽  
In Vivo Evaluation ◽  
Hydrophobic Matrix

Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation

2016 ◽  
Vol 27 (6) ◽  
Author(s):  
Furqan A. Maulvi ◽  
Mayurkumar A. Mangukiya ◽  
Prachi A. Patel ◽  
Rutvi J. Vaidya ◽  
Akshay R. Koli ◽  
...  
Keyword(s):  
Extended Release ◽  
Contact Lenses ◽  
Silica Shell ◽  
In Vivo Evaluation

In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug

1996 ◽  
Vol 139 (1-2) ◽  
pp. 79-85 ◽  
Author(s):  
J.D. Ntawukulilyayo ◽  
C. Vervaet ◽  
J.P. Remon ◽  
J.P. Görtz ◽  
J.A. Berlo
Keyword(s):  
Xanthan Gum ◽  
Matrix Tablet ◽  
In Vivo Evaluation ◽  
Model Drug

In Vitro and In Vivo Evaluation of Two Extended Release Preparations of Combination Metformin and Glipizide

2005 ◽  
Vol 31 (7) ◽  
pp. 677-685 ◽  
Author(s):  
Ouyang Defang ◽  
Nie Shufang ◽  
Li Wei ◽  
Guo Hong ◽  
Liu Hui ◽  
...  
Keyword(s):  
Extended Release ◽  
In Vivo Evaluation

scholarly journals In Vitro - In Vivo Evaluation Of E/R Trilayer Matrix Tablets Containing Solid Dispersion Of Atorvastatin

2016 ◽  
Vol 8 (3) ◽  
pp. 107
Author(s):  
A Thirupathaiah ◽  
R Shyam Sunder
Keyword(s):  
Extended Release ◽  
Chemical Interaction ◽  
Research Work ◽  
Matrix Tablets ◽  
Drug Dissolution ◽  
Matrix Tablet ◽  
Dissolution Profile ◽  
Reference Standard

<p>Investigation of <em>in vitro/in vivo</em> behaviour of extended release tablets containing solid dispersions of Atorvastatin is the focus of the present research work. Atorvastatin trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropylmethylcellulose (HPMC), ethyl cellulose and Carbopol 934P. Barrier layers are prepared with hydrophobic polymers carnauba wax and xanthan gum. Based on the evaluation parameters, drug dissolution profile and release order kinetics HF16 was found to be optimized formulation. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF16) was described by the Zero-order and best fitted to Higuchi model. FTIR confirmed that there was no chemical interaction between drug and excipients used in the formulation. . In vivo bioavailability studies were conducted for optimized formulation HF16 and reference standard. The optimized formulation of Atorvastatin trilayer matrix tablet was shown significant plasma concentration with extended release and maintained for 24 hrs with patient compliance by reducing the dosage frequency, when compared with reference standard. </p>

Sign in / Sign up

Export Citation Format

Share Document