In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug

1996 ◽  
Vol 139 (1-2) ◽  
pp. 79-85 ◽  
Author(s):  
J.D. Ntawukulilyayo ◽  
C. Vervaet ◽  
J.P. Remon ◽  
J.P. Görtz ◽  
J.A. Berlo
Keyword(s):  
Xanthan Gum ◽  
Matrix Tablet ◽  
In Vivo Evaluation ◽  
Model Drug

SUSTAINED RELEASE HYDROPHILIC MATRICES BASED ON XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE: DEVELOPMENT, OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION

2010 ◽  
Vol 2 ◽  
pp. 89-103
Author(s):  
Muhammad Sajid Hamid Akash . ◽  
Ikram Ullah Khan . ◽  
Syed Nisar Hussain Shah . ◽  
Sajid Asghar . ◽  
Asif massud . ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
In Vivo Evaluation ◽  
Hydrophilic Matrices

Sustained-Release and Swelling Characteristics of Xanthan Gum/Ethylcellulose-Based Injection Moulded Matrix Tablets: in Vitro and in Vivo Evaluation

2011 ◽  
Vol 100 (7) ◽  
pp. 2858-2870 ◽  
Author(s):  
T. Quinten ◽  
T. De Beer ◽  
F.O. Onofre ◽  
G. Mendez-Montealvo ◽  
Y.J. Wang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Matrix Tablets ◽  
In Vivo Evaluation ◽  
Swelling Characteristics

In vitro and in vivo evaluation of xanthan gum–succinic anhydride hydrogels for the ionic strength-sensitive release of antibacterial agents

2016 ◽  
Vol 4 (10) ◽  
pp. 1853-1861 ◽  
Author(s):  
Bailiang Wang ◽  
Yuemei Han ◽  
Quankui Lin ◽  
Huihua Liu ◽  
Chenghui Shen ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Xanthan Gum ◽  
Succinic Anhydride ◽  
Antibacterial Agents ◽  
Lower Degree ◽  
Infection Model ◽  
In Vivo Evaluation

XG–SA/GS hydrogels yielded a significantly lower degree of infection than native XG–SA hydrogels in an in vivo rabbit subcutaneous S. aureus infection model at day 7.

scholarly journals FORMULATION AND IN-VITRO-IN-VIVO EVALUATION OF ALGINATE-CHITOSAN MICROSPHERES OF GLIPIZIDE BY IONIC GELATION METHOD

2017 ◽  
Vol 10 (7) ◽  
pp. 385 ◽  
Author(s):  
Maya Sharma ◽  
Choudhury Pk ◽  
Suresh Kumar Dev
Keyword(s):  
Sustained Release ◽  
Dosage Form ◽  
Oral Dosage ◽  
Ionic Gelation ◽  
In Vivo Evaluation ◽  
Chitosan Microspheres ◽  
Model Drug ◽  
Effective Use

Objective: The present work is aimed to formulate and evaluate alginate-chitosan microspheres of glipizide for the effective use in the treatment of diabetes.Methods: Sustained release microspheres were prepared by gentle mixing of polymers in water phase with drug by agitation. The polymers used for preparation were sodium alginate and chitosan, which was extruded into 5% calcium chloride solution to produce microspheres by ionic gelation method.Results: Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug evenly throughout the stomach which suppresses the irritation. The aim of study towards formulation and evaluation of alginate-chitosan microspheres, which can provide sustained release of the model drug. It shows better in-vitro and in-vivo activity than conventional dosage forms. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form. Conclusion:  Drugs that are simply absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated rapidly from the blood flow. To avoid this trouble, the oral sustained release (SR) has been developed as these will release the drug slowly in to the GIT and maintain a stable drug concentration in the serum for a longer period of time.

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