Inhibitory Effect of Platelet-Activating Factor (PAF) on Luteinizing Hormone-Releasing Hormone and Somatostatin Release From Rat Median Eminencein VitroCorrelated with the Characterization of Specific PAF Receptor Sites in Rat Hypothalamus

Endocrinology ◽  
1988 ◽  
Vol 123 (1) ◽  
pp. 72-80 ◽  
Author(s):  
M. P. JUNIER ◽  
C. TIBERGHIEN ◽  
C. ROUGEOT ◽  
V. FAFEUR ◽  
F. DRAY
Keyword(s):  
Luteinizing Hormone ◽  
Platelet Activating Factor ◽  
Inhibitory Effect ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Rat Hypothalamus ◽  
Receptor Sites ◽  
Paf Receptor

FURTHER STUDIES ON ENZYMIC INACTIVATION OF LUTEINIZING HORMONE – RELEASING HORMONE (LH-RH) BY PEPTIDASES IN THE RAT HYPOTHALAMUS

1975 ◽  
Vol 79 (1) ◽  
pp. 7-15 ◽  
Author(s):  
E. C. Griffiths ◽  
K. C. Hooper ◽  
C. R. N. Hopkinson
Keyword(s):  
Enzyme Activity ◽  
Luteinizing Hormone ◽  
Assay System ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Rat Hypothalamus ◽  
Lh Rh ◽  
A Site

ABSTRACT Luteinizing hormone-releasing hormone (LH-RH) is known to be inactivated by peptidases in the rat hypothalamus with consequent loss of LH-releasing ability. To make a further study of the peptidases' action on the decapeptide, synthetic LH-RH and its [1–9NH2] analogue were incubated with the supernatant hypothalamic fraction containing the enzyme activity. Using an assay system measuring gonadotrophin release in ovariectomized/steroid-primed rats, both LH-RH and the [1–9NH2] analogue were found to be inactivated to different extents after incubation with the fraction, the analogue completely losing both LH- and FSH-releasing activity, and the releasing hormone almost completely losing its LH- and totally losing its FSH-releasing activity. The findings extend the initial studies by showing that the peptidases can remove both the decapeptide's intrinsic LH- and FSH-releasing activity and that these enzymes act on LH-RH at a site other than the C-terminal glycinamide, since they are able to inactivate the [1–9NH2] analogue lacking this residue.

scholarly journals Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

1972 ◽  
Vol 6 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Abba J Kastin ◽  
Andrew V Schally ◽  
Don S Schalch ◽  
Stanley G Korenman ◽  
M Clinton Miller ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormonal Responses ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Lh Rh

scholarly journals The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen

2004 ◽  
Vol 101 (32) ◽  
pp. 11891-11896 ◽  
Author(s):  
C. Scorticati ◽  
J. Fernandez-Solari ◽  
A. De Laurentiis ◽  
C. Mohn ◽  
J. P. Prestifilippo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Inhibitory Effect ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone
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