Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84)

Endocrinology ◽  
1995 ◽  
Vol 136 (11) ◽  
pp. 4732-4740 ◽  
Author(s):  
N Inomata ◽  
M Akiyama ◽  
N Kubota ◽  
H Jüppner
Keyword(s):  
Parathyroid Hormone ◽  
Terminal Region ◽  
Carboxyl Terminal

scholarly journals Receptors Specific for the Carboxyl-Terminal Region of Parathyroid Hormone on Bone-Derived Cells: Determinants of Ligand Binding and Bioactivity

Endocrinology ◽  
2005 ◽  
Vol 146 (4) ◽  
pp. 1863-1870 ◽  
Author(s):  
P. Divieti ◽  
A. I. Geller ◽  
G. Suliman ◽  
H. Jüppner ◽  
F. R. Bringhurst
Keyword(s):  
Parathyroid Hormone ◽  
Ligand Binding ◽  
Terminal Region ◽  
Carboxyl Terminal

Parathyrin radioimmunoassay: diagnostic utility of antisera produced against carboxyl-terminal fragments of the hormone from the human.

1978 ◽  
Vol 24 (3) ◽  
pp. 451-454 ◽  
Author(s):  
F P Di Bella ◽  
J M Kehrwald ◽  
K Laakso ◽  
L Zitzner
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Guinea Pigs ◽  
Normal Subjects ◽  
Terminal Region ◽  
Diagnostic Utility ◽  
Human Origin ◽  
Widespread Availability ◽  
Carboxyl Terminal

Abstract Antisera directed toward the carboxyl-terminal region of human parathyrin (parathyroid hormone), for use in daignostically applicable radioimmunoassays of the hormone in serum, are scarce, largely because of the lack of suitable immunogens of human origin. We produced four antisera in goats and guinea pigs by immunization with recently discovered carboxyl-terminal fragments of human parathyrin extracted from parathyroid tumors. Here, we report results of radioimmunoassays of nearly 200 normal and pathological sera with one of these antisera; we observed almost complete differentiation between concentrations of parathyrin in serum of healthy normal subjects and patients with primary, secondary (due to chronic renal failure), or "ectopic" hyperparathyroidism (due to nonparathyroid cancer). The availability of a new immunogen should now make possible the deliberate production of large quantities of diagnostically applicable parathyrin antisera directed toward the carboxyl-terminal region of human parathyrin. This should, in turn, lead to more widespread availability of this useful radioimmunoassay.

scholarly journals Identification and Characterization of the Carboxyl-terminal Region of Rat Dentin Sialoprotein

2000 ◽  
Vol 276 (2) ◽  
pp. 904-909 ◽  
Author(s):  
Chunlin Qin ◽  
Richard G. Cook ◽  
Ralph S. Orkiszewski ◽  
William T. Butler
Keyword(s):  
Terminal Region ◽  
Carboxyl Terminal ◽  
Dentin Sialoprotein ◽  
Identification And Characterization

Expression, purification, and characterization of the carboxyl-terminal region of the Na+/H+ exchanger

1998 ◽  
Vol 76 (5) ◽  
pp. 837-842 ◽  
Author(s):  
Daniel Gebreselassie ◽  
Krishna Rajarathnam ◽  
Larry Fliegel
Keyword(s):  
Terminal Region ◽  
Purification And Characterization ◽  
Carboxyl Terminal

scholarly journals Synthesis and characterization of novel biotinylated carboxyl-terminal parathyroid hormone peptides that specifically crosslink to the CPTH-receptor

Peptides ◽  
2006 ◽  
Vol 27 (12) ◽  
pp. 3352-3362 ◽  
Author(s):  
Santanu Banerjee ◽  
Hafez Selim ◽  
Gihan Suliman ◽  
Andrew I. Geller ◽  
Harald Jüppner ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Synthesis And Characterization ◽  
Carboxyl Terminal

Characterization of Antisera Distinguishing Carbohydrate Structures in the β-Carboxyl-Terminal Region of Human Chorionic Gonadotropin*

Endocrinology ◽  
1988 ◽  
Vol 122 (5) ◽  
pp. 2054-2063 ◽  
Author(s):  
STEVEN BIRKEN ◽  
GLADYS AGOSTO ◽  
SANIA AMR ◽  
BRUCE NISULA ◽  
LAURENCE COLE ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Terminal Region ◽  
Carboxyl Terminal
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