Protracted 1,25-dihydroxyvitamin D treatment stimulates multiple calmodulin binding proteins in rat kidney.

Endocrinology ◽  
1995 ◽  
Vol 136 (4) ◽  
pp. 1516-1522 ◽  
Author(s):  
S D Antrobus ◽  
E K Siaw ◽  
M R Walters
Keyword(s):  
Binding Proteins ◽  
Rat Kidney ◽  
Dihydroxyvitamin D ◽  
Calmodulin Binding ◽  
1,25 Dihydroxyvitamin D

1,25-Dihydroxyvitamin D-stimulated calmodulin binding proteins: a sustained effect on distal tubules

2002 ◽  
Vol 282 (1) ◽  
pp. F77-F84 ◽  
Author(s):  
Emmanuel K. O. Siaw ◽  
Marian R. Walters
Keyword(s):  
Vitamin D ◽  
Time Course ◽  
Binding Proteins ◽  
Day Treatment ◽  
Rat Kidney ◽  
Vitamin D Receptors ◽  
Dihydroxyvitamin D ◽  
Calmodulin Binding ◽  
1,25 Dihydroxyvitamin D

The tubular localization of 1,25-dihydroxyvitamin D[1,25(OH)2D3]-stimulated calmodulin binding proteins (CaMBP-Ds) in the rat kidney and the specificity of their induction were characterized to better understand renal responses to protracted 1,25(OH)2D3 treatment in vivo. None of the other hormones tested (parathyroid hormone, calcitonin, estradiol-17β, testosterone, progesterone, hydrocortisone, or dexamethasone) stimulated the CaMBP-Ds, whereas maximal 1,25(OH)2D3 stimulation occurred after a 5- to 7-day treatment with 100 ng/day 1,25(OH)2D3. With the exception of the more ubiquitously distributed CaMBP-D150, the CaMBP-Ds were localized in distal, but not proximal, tubule preparations. 1,25(OH)2D3 induction of vitamin D receptors and the CaMBP-Ds was similar with respect to dose-response and time course. Finally, the CaMBP-Ds remained elevated for at least 4 wk after 1,25(OH)2D3 withdrawal. Because the vitamin D-stimulated renal CaMBP-Ds are principally proteins of the distal tubule, they may be associated with renal regulation of Ca2+ homeostasis. The sustained induction of CaMBP-Ds is important in addressing the question of whether their induction is a function of normal Ca2+ homeostasis or a pathophysiological consequence of hypervitaminosis D and hypercalcemia.

Preconditioning with 1,25-Dihydroxyvitamin D3 Protects against Subsequent Ischemia-Reperfusion Injury in the Rat Kidney

2005 ◽  
Vol 100 (2) ◽  
pp. e85-e94 ◽  
Author(s):  
Young Ok Kim ◽  
Can Li ◽  
Bo Kyung Sun ◽  
Jung Sim Kim ◽  
Sun Woo Lim ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Rat Kidney ◽  
Ischemia Reperfusion ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

Developmental changes in rat kidney 1,25-dihydroxyvitamin D receptor

1990 ◽  
Vol 170 (1) ◽  
pp. 65-72 ◽  
Author(s):  
N.J. Koszewski ◽  
T.A. Reinhardt ◽  
D.C. Beitz ◽  
R.L. Horst
Keyword(s):  
Rat Kidney ◽  
Developmental Changes ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

1,25-Dihydroxyvitamin D3 Stimulates Osteopontin Expression in Rat Kidney

2003 ◽  
Vol 93 (3) ◽  
pp. p76-p86 ◽  
Author(s):  
Ki-Hwan Han ◽  
Ju-Young Jung ◽  
Jung-Ho Cha ◽  
Hyang Kim ◽  
Kirsten M. Madsen ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Dihydroxyvitamin D ◽  
Osteopontin Expression ◽  
1,25 Dihydroxyvitamin D
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