Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus)

2009 ◽  
Vol 61 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Kalina Venkova ◽  
Helmut Thomas ◽  
Graeme L. Fraser ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Receptor Antagonist ◽  
Suncus Murinus ◽  
Musk Shrew ◽  
Motilin Receptor

Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus)

2009 ◽  
Vol 61 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Kalina Venkova ◽  
Helmut Thomas ◽  
Graeme L. Fraser ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Receptor Antagonist ◽  
Suncus Murinus ◽  
Musk Shrew ◽  
Motilin Receptor

Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994

1995 ◽  
Vol 34 (12) ◽  
pp. 1697-1699 ◽  
Author(s):  
F.D. Tattersall ◽  
W. Rycroft ◽  
N. Marmont ◽  
M. Cascieri ◽  
R.G. Hill ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Nk1 Receptor ◽  
Suncus Murinus ◽  
Musk Shrew ◽  
Nk1 Receptor Antagonist

The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9–39) in Suncus murinus (house musk shrew)

2014 ◽  
Vol 83 ◽  
pp. 71-78 ◽  
Author(s):  
Sze Wa Chan ◽  
Zengbing Lu ◽  
Ge Lin ◽  
David Tai Wai Yew ◽  
Chi Kong Yeung ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Suncus Murinus ◽  
Musk Shrew

scholarly journals Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus)

2009 ◽  
Vol 296 (4) ◽  
pp. R902-R911 ◽  
Author(s):  
Bart C. De Jonghe ◽  
Charles C. Horn
Keyword(s):  
Receptor Antagonist ◽  
Area Postrema ◽  
Neural System ◽  
Central Nucleus ◽  
Motor Nucleus ◽  
Suncus Murinus ◽  
Musk Shrew ◽  
Chemotherapy Drugs ◽  
Chemotherapy Agent ◽  
Fos Expression

Cancer chemotherapy drugs, such as cisplatin, potently produce nausea and vomiting. Acute effects of these treatments are partly controlled by antiemetic drugs, but the delayed effects (>24 h), especially nausea, are more difficult to treat. It is unknown what brain pathways produce this delayed sickness. Our prior data show that brain Fos expression is increased for at least 48 h after cisplatin treatment in the rat, a nonvomiting species. Here, we extend these observations by using house musk shrews ( Suncus murinus), a species with an emetic response. Compared with saline injection, cisplatin treatment (30 mg/kg ip) induced Fos expression in hindbrain areas known to play a role in the generation of emesis, the dorsal motor nucleus (DMN), the area postrema, and the nucleus of the solitary tract (NTS), for up to 48 h. Cisplatin also stimulated Fos expression in the parabrachial nucleus (PBN) of the midbrain and the central nucleus of the amygdala (CeA) for at least 48 h after treatment. When animals were pretreated with the antiemetic palonosetron, a long-term serotonin type 3 (5-HT3) receptor antagonist, cisplatin-induced Fos expression was significantly attenuated in the NTS, DMN, and CeA at 6 h but not at 48 h. These results indicate that cisplatin activates a neural system that includes the dorsal vagal complex and forebrain in the musk shrew, which is partially suppressed by a 5-HT3 receptor antagonist. Our findings suggest the existence of an extensive neural system that could be targeted to reduce nausea, vomiting, and malaise in cancer patients receiving chemotherapy.

Scent marking in the musk shrew (Suncus murinus)

1987 ◽  
Vol 39 (6) ◽  
pp. 677-680 ◽  
Author(s):  
Leeanne E. Tennant ◽  
Emilie F. Rissman ◽  
F.H. Bronson
Keyword(s):  
Scent Marking ◽  
Suncus Murinus ◽  
Musk Shrew

scholarly journals Morphogenesis of Esophageal Carcinoma Induced by N-Methyl-N′-nitro-N-nitrosoguanidine in the House Musk Shrew, Suncus murinus (Insectivora)

1994 ◽  
Vol 85 (12) ◽  
pp. 1208-1213 ◽  
Author(s):  
Yoshiko Fujita ◽  
Tatsuki Oyaizu ◽  
Hideki Takahashi ◽  
Yuji Oishi ◽  
Airo Tsubura
Keyword(s):  
Esophageal Carcinoma ◽  
Suncus Murinus ◽  
Musk Shrew

scholarly journals Morphological Study on the Intestine of the Musk Shrew, Suncus murinus

1980 ◽  
Vol 42 (1) ◽  
pp. 61-67,71 ◽  
Author(s):  
Masamichi KUROHMARU ◽  
Takao NISHIDA ◽  
Koshi MOCHIZUKI
Keyword(s):  
Morphological Study ◽  
Suncus Murinus ◽  
Musk Shrew
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