Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual field defects

Neurology ◽  
1999 ◽  
Vol 53 (5) ◽  
pp. 922-922 ◽  
Author(s):  
R. Kalviainen ◽  
I. Nousiainen ◽  
M. Mantyjarvi ◽  
E. Nikoskelainen ◽  
J. Partanen ◽  
...  
Keyword(s):  
Visual Field ◽  
Antiepileptic Drug ◽  
Visual Field Defects ◽  
Field Defects

scholarly journals Visual field defects in patients on chronic antiepileptic drug treatment

Seizure ◽  
1998 ◽  
Vol 7 (5) ◽  
pp. 422
Author(s):  
J.P. Leach ◽  
P. Rao ◽  
F. Alfat ◽  
G. Kyle ◽  
D.W. Chadwick
Keyword(s):  
Visual Field ◽  
Drug Treatment ◽  
Antiepileptic Drug ◽  
Visual Field Defects ◽  
Antiepileptic Drug Treatment ◽  
Field Defects

scholarly journals Visual Defects Associated with Vigabatrin: A Study of Epileptic Argentine Patients

2005 ◽  
Vol 32 (4) ◽  
pp. 459-464 ◽  
Author(s):  
María Cecilia Moreno ◽  
Brenda Giagante ◽  
Patricia Saidon ◽  
Silvia Kochen ◽  
Jorge Benozzi ◽  
...  
Keyword(s):  
Visual Field ◽  
Antiepileptic Drug ◽  
Screening Test ◽  
Screening Strategy ◽  
Visual Field Defects ◽  
Automated Perimetry ◽  
Field Screening ◽  
Full Field ◽  
Visual Defects ◽  
Field Defects

ABSTRACT:Objective:The aim of the present study was to assess visual alterations in a population of Argentine patients treated with the antiepileptic drug vigabatrin.Methods:Twenty patients receiving vigabatrin and 15 patients receiving carbamazepine were examined with automated perimetry using a Humphrey 120-point full screening strategy. In addition, scotopic flash electroretinograms were performed.Results:Of 20 patients treated with vigabatrin, two were unable to cooperate with testing. Of the remaining 18 patients, all but two showed at least one non-detected point inside the central 40° of the visual field of each eye. Of the 15 carbamazepine-treated patients, three were unable to perform the study. None of the remaining 12 patients showed visual field defects. Both a- and b-wave amplitudes of the scotopic electroretinogram were significantly reduced in 12 patients receiving vigabatrin.Conclusions:Visual field defects among patients on vigabatrin therapy may occur with a higher frequency than previously recognized. The Humphrey 120-points full field screening test and electroretinography are useful tools to assess the visual dysfunction associated with vigabatrin.

scholarly journals Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

2019 ◽  
Vol 7 (1) ◽  
pp. e00456 ◽  
Author(s):  
Dana C. Walters ◽  
Erwin E. W. Jansen ◽  
Garrett R. Ainslie ◽  
Gajja S. Salomons ◽  
Madalyn N. Brown ◽  
...  
Keyword(s):  
Visual Field ◽  
Antiepileptic Drug ◽  
Tissue Distribution ◽  
Visual Field Defects ◽  
Potential Use ◽  
Field Defects

scholarly journals Study is needed of visual field defects associated with any long term antiepileptic drug

BMJ ◽  
1998 ◽  
Vol 317 (7152) ◽  
pp. 206-206 ◽  
Author(s):  
G P. Rao ◽  
F. A. Fat ◽  
G. Kyle ◽  
J. P. Leach ◽  
D. W Chadwick ◽  
...  
Keyword(s):  
Visual Field ◽  
Antiepileptic Drug ◽  
Visual Field Defects ◽  
Field Defects

scholarly journals Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes

2021 ◽  
Vol 223 ◽  
pp. 229-240
Author(s):  
Eren Ekici ◽  
Sasan Moghimi ◽  
Huiyuan Hou ◽  
James Proudfoot ◽  
Linda M. Zangwill ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Visual Field Defects ◽  
Central Visual Field ◽  
Field Defects

Computerized color perimetry in multiple sclerosis

1998 ◽  
Vol 4 (2) ◽  
pp. 79-84 ◽  
Author(s):  
N Accornero ◽  
S Rinalduzzi ◽  
M Capozza ◽  
E Millefiorini ◽  
G C Filligoi ◽  
...  
Keyword(s):  
Visual Field ◽  
Statistical Difference ◽  
Cost Effective ◽  
Quantitative Information ◽  
Field Analysis ◽  
Visual Field Defects ◽  
Highly Sensitive ◽  
The Subject ◽  
Color Perimetry ◽  
Field Defects

Color visual field analysis has proven highly sensitive for early visual impairments diagnosis in MS, yet it has never attained widespread popularity usually because the procedure is difficult to standardize, the devices are costly, and the test is fatiguing. We propose a computerized procedure running on standard PC, cost effective, clonable, and easy handled. Two hundred and sixty-four colored patches subtending 18 angle of vision, with selected hues and low saturation levels are sequentially and randomly displayed on gray equiluminous background of the PC screen subtending 2486408 angle of vision. The subject is requested to press a switch at the perception of the stimulus. The output provides colored maps with quantitative information. Comparison between normals and a selected population of MS patients with no actual luminance visual field defects, showed high statistical difference.

Sign in / Sign up

Export Citation Format

Share Document