Dialdehyde Production during Direct Dissociation of Energy-rich Criegee Intermediates Produced by Ozonolysis of Cycloalkenes

2016 ◽  
Vol 45 (8) ◽  
pp. 916-918 ◽  
Author(s):  
Phil A. Brown ◽  
Satoshi Inomata ◽  
Hiroshi Tanimoto ◽  
Kei Sato ◽  
Yosuke Sakamoto ◽  
...  
Keyword(s):  
Criegee Intermediates ◽  
Direct Dissociation

Substituent Effect in the Reactions between Criegee Intermediates and 3-Aminopropanol

2021 ◽  
Author(s):  
Mei-Tsan Kuo ◽  
Jie-Ning Yang ◽  
Jim Jr-Min Lin ◽  
Kaito Takahashi
Keyword(s):  
Substituent Effect ◽  
Criegee Intermediates

scholarly journals Borrelidin from Saltern-Derived Halophilic Nocardiopsis sp. Dissociates Amyloid-β and Tau Fibrils

2020 ◽  
pp. 1-7
Author(s):  
Jisu Shin ◽  
Seung-Hoon Yang ◽  
Young Eun Du ◽  
Keunwan Park ◽  
DaWon Kim ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Thioflavin T ◽  
Drug Candidate ◽  
Ht22 Cells ◽  
Aβ Aggregation ◽  
Actinomycete Strain ◽  
Direct Dissociation ◽  
Aβ Fibrils ◽  
Tau Aggregation

Background: Alzheimer’s disease (AD) is characterized by the aggregation of two pathological proteins, amyloid-β (Aβ) and tau, leading to neuronal and cognitive dysfunction. Clearance of either Aβ or tau aggregates by immunotherapy has become a potential therapy, as these aggregates are found in the brain ahead of the symptom onset. Given that Aβ and tau independently and cooperatively play critical roles in AD development, AD treatments might require therapeutic approaches to eliminate both aggregates together. Objective: We aimed to discover a chemical drug candidate from natural sources for direct dissociation of both insoluble Aβ and tau aggregates through in vitro assessments. Methods: We isolated four borrelidin chemicals from a saltern-derived halophilic actinomycete strain of rare genus Nocardiopsis and simulated their docking interactions with Aβ fibrils. Then, anti-cytotoxic, anti-Aβ, and anti-tau effects of borrelidins were examined by MTT assays with HT22 hippocampal cell line, thioflavin T assays, and gel electrophoresis. Results: When HT22 cells were exposed to Aβ aggregates, the treatment of borrelidins alleviates the Aβ-induced toxicity. These anti-cytotoxic effects can be derived from the inhibitory functions of borrelidins against the Aβ aggregation as shown in thioflavin T and gel electrophoretic analyses. Among them, especially borrelidin, which exhibits the highest probability of docking, not only dissociates Aβ aggregates but also directly regulates tau aggregation. Conclusion: Borrelidin dissociates insoluble Aβ and tau aggregates together and our findings support the view that it is possible to develop an alternative chemical approach mimicking anti-Aβ or anti-tau immunotherapy for clearance of both aggregates.

scholarly journals Open questions on the reactivity of Criegee intermediates

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Rebecca L. Caravan ◽  
Michael F. Vansco ◽  
Marsha I. Lester
Keyword(s):  
Criegee Intermediates ◽  
Open Questions

scholarly journals Deep tunneling in the unimolecular decay of CH3CHOO Criegee intermediates to OH radical products

2016 ◽  
Vol 145 (23) ◽  
pp. 234308 ◽  
Author(s):  
Yi Fang ◽  
Fang Liu ◽  
Victoria P. Barber ◽  
Stephen J. Klippenstein ◽  
Anne B. McCoy ◽  
...  
Keyword(s):  
Oh Radical ◽  
Criegee Intermediates

scholarly journals Tunneling effects in the unimolecular decay of (CH3)2COO Criegee intermediates to OH radical products

2017 ◽  
Vol 146 (13) ◽  
pp. 134307 ◽  
Author(s):  
Yi Fang ◽  
Victoria P. Barber ◽  
Stephen J. Klippenstein ◽  
Anne B. McCoy ◽  
Marsha I. Lester
Keyword(s):  
Oh Radical ◽  
Criegee Intermediates

scholarly journals Direct observation of unimolecular decay of CH3CH2CHOO Criegee intermediates to OH radical products

2016 ◽  
Vol 145 (4) ◽  
pp. 044312 ◽  
Author(s):  
Yi Fang ◽  
Fang Liu ◽  
Stephen J. Klippenstein ◽  
Marsha I. Lester
Keyword(s):  
Direct Observation ◽  
Oh Radical ◽  
Criegee Intermediates

Femtosecond Real-Time Probing of Reactions. 17. Centrifugal Effects in Direct Dissociation Reactions

1995 ◽  
Vol 99 (9) ◽  
pp. 2520-2529 ◽  
Author(s):  
Gareth Roberts ◽  
Ahmed H. Zewail
Keyword(s):  
Real Time ◽  
Direct Dissociation

Vibrational Predissociation of the He - I 2 (B, v = 34) - Ne Complex: Sequential Mechanism and Direct Dissociation

1990 ◽  
pp. 517-524 ◽  
Author(s):  
P. Villarreal ◽  
S. Miret-Artés ◽  
J. Campos-Martínez ◽  
G. Delgado-Barrio
Keyword(s):  
Vibrational Predissociation ◽  
Sequential Mechanism ◽  
Direct Dissociation

Pressure Stabilization of Criegee Intermediates Formed from Symmetric trans-Alkene Ozonolysis

2018 ◽  
Vol 122 (49) ◽  
pp. 9426-9434 ◽  
Author(s):  
Jani P. Hakala ◽  
Neil M. Donahue
Keyword(s):  
Criegee Intermediates ◽  
Pressure Stabilization
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