scholarly journals Hydrolysis of salicyluric acid in intestinal microorganisms and prolonged blood concentration of salicylic acid following rectal administration of salicyluric acid in rats.

1988 ◽  
Vol 11 (9) ◽  
pp. 625-629 ◽  
Author(s):  
Junzo NAKAMURA ◽  
Hideo SHIOTA ◽  
Hitoshi SASAKI ◽  
Juichiro SHIBASAKI
Keyword(s):  
Salicylic Acid ◽  
Blood Concentration ◽  
Rectal Administration ◽  
Intestinal Microorganisms ◽  
Salicyluric Acid ◽  
Hydrolysis Of

scholarly journals Effect of fasting on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms.

1989 ◽  
Vol 12 (10) ◽  
pp. 602-607 ◽  
Author(s):  
Junzo NAKAMURA ◽  
Yoko HARAGUCHI ◽  
Hitoshi SASAKI ◽  
Juichiro SHIBASAKI
Keyword(s):  
Intestinal Microorganisms ◽  
Salicyluric Acid ◽  
Hydrolysis Of

scholarly journals Unequal Hydrolysis of Salicylic Acid-D-Alanine and Salicylic Acid-L-Alanine Conjugate in Rabbit Intestinal Microorganisms.

1992 ◽  
Vol 40 (2) ◽  
pp. 547-549 ◽  
Author(s):  
Junzo NAKAMURA ◽  
Chieko TAGAMI ◽  
Koyo NISHIDA ◽  
Hitoshi SASAKI
Keyword(s):  
Salicylic Acid ◽  
Intestinal Microorganisms ◽  
Hydrolysis Of

scholarly journals Hydrolysis of salicyluric acid in rabbit intestinal microorganisms.

1985 ◽  
Vol 8 (12) ◽  
pp. 989-995 ◽  
Author(s):  
JUICHIRO SHIBASAKI ◽  
YOSHIO INOUE ◽  
KATSUNORI KADOSAKI ◽  
HITOSHI SASAKI ◽  
JUNZO NAKAMURA
Keyword(s):  
Intestinal Microorganisms ◽  
Salicyluric Acid ◽  
Hydrolysis Of

scholarly journals Sustained blood concentrations of salicylic acid following rectal administration of salicyluric acid in dogs.

1989 ◽  
Vol 37 (9) ◽  
pp. 2537-2538 ◽  
Author(s):  
Junzo NAKAMURA ◽  
Hideo SHIOTA ◽  
Hitoshi SASAKI ◽  
Juichiro SHIBASAKI
Keyword(s):  
Salicylic Acid ◽  
Rectal Administration ◽  
Blood Concentrations ◽  
Salicyluric Acid

scholarly journals Effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms.

1990 ◽  
Vol 13 (8) ◽  
pp. 461-467 ◽  
Author(s):  
Junzo NAKAMURA ◽  
Yoko HARAGUCHI ◽  
Kumiko ASAI ◽  
Hitoshi SASAKI ◽  
Juichiro SHIBASAKI
Keyword(s):  
Intestinal Microorganisms ◽  
Salicyluric Acid ◽  
Hydrolysis Of

Simultaneous liquid-chromatographic quantitation of salicylic acid, salicyluric acid, and gentisic acid in urine.

1980 ◽  
Vol 26 (1) ◽  
pp. 111-114
Author(s):  
B E Cham ◽  
F Bochner ◽  
D M Imhoff ◽  
D Johns ◽  
M Rowland
Keyword(s):  
Salicylic Acid ◽  
Internal Standard ◽  
Peak Height ◽  
Reversed Phase ◽  
Gentisic Acid ◽  
Salicyluric Acid ◽  
Analytical Recovery ◽  
Volume Response ◽  
Assay Precision ◽  
Liquid Chromatographic

Abstract We have developed a specific and sensitive method for the determination of salicylic acid, salicyluric acid, and gentisic acid in urine. Any proteins present are precipitated with methyl cyanide. After centrifugation, an aliquot of the supernate is directly injected into an octadecyl silane reversed-phase chromatographic column, then eluted with a mixture of water, butanol, acetic acid, and sodium sulfate, and quantitated at 313 nm by ultraviolet detection according to peak-height ratios (with internal standard, o-methoxybenzoic acid) or peak heights (no internal standard). The method allows estimates within 25 min. Sensitivity was 0.2 mg/L for gentisic acid, and 0.5 mg/L for both salicyluric and salicylic acid (20-micro L injection volume); response was linear with concentration to at least 2.000 g/L for salicylic acid and metabolites. Analytical recovery of salicylic acid and metabolites from urine is complete. Intra-assay precision (coefficient of variation) is 5.52% at 7.5 mg/L for salicylic acid, 5.01% at 9.33 mg/L for salicyluric acid, and 3.07% at 7.96 mg/L for gentisic acid. Interassay precision is 7.32% at 7.51 mg/L for salicylic acid, 5.52% at 8.58 mg/L for salicyluric acid, and 3.97% at 8.32 mg/L for gentisic acid. We saw no significant interference in urine from patients being treated with various drugs other than aspirin.

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