Cardiovascular safety pharmacology: in vitro strategies and improvements in technology and evaluation

Folia Pharmacologica Japonica ◽

10.1254/fpj.21031 ◽

2021 ◽

Vol 156 (5) ◽

pp. 297-302

Author(s):

Takashi Yoshinaga

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology

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Establishing in vitro to clinical correlations in the evaluation of cardiovascular safety pharmacology

Drug Discovery Today Technologies ◽

10.1016/j.ddtec.2012.07.001 ◽

2013 ◽

Vol 10 (3) ◽

pp. e373-e383 ◽

Author(s):

A.S.Y. Chain ◽

M.C.J.M. Sturkenboom ◽

M. Danhof ◽

O.E. Della Pasqua

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology ◽

Clinical Correlations

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A SPS Survey on Cardiovascular Safety Pharmacology Practices Assessing Proarrhythmia Risk in Drug Safety Testing: State of the Art Prior to Implementation of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) Paradigm

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2017.09.250 ◽

2017 ◽

Vol 88 ◽

pp. 245

Author(s):

Michael K. Pugsley ◽

Bernard Fermini ◽

John Koerner ◽

Krystle Correll ◽

Simon Authier ◽

...

Keyword(s):

Drug Safety ◽

State Of The Art ◽

Cardiovascular Safety ◽

Safety Testing ◽

Safety Pharmacology

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In Vitro Early Safety Pharmacology Screening: Perspectives Related to Cardiovascular Safety

Principles of Safety Pharmacology - Handbook of Experimental Pharmacology ◽

10.1007/978-3-662-46943-9_2 ◽

2015 ◽

pp. 47-64 ◽

Author(s):

Gary Gintant

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology

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In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

Food and Chemical Toxicology ◽

10.1016/j.fct.2018.09.047 ◽

2018 ◽

Vol 121 ◽

pp. 541-548 ◽

Author(s):

John C. Fuller ◽

Lisa M. Pitchford ◽

Ryan D. Morrison ◽

J. Scott Daniels ◽

Charles R. Flynn ◽

...

Keyword(s):

Safety Pharmacology

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4. Methods in Cardiovascular Safety Pharmacology

10.1007/springerreference_42979 ◽

2011 ◽

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology

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A patient-centric CRISPR-Cas9 in vitro cardiovascular safety model to examine genetic variability in calcium handling and its impact on drug-induced cardiotoxicity

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2019.05.183 ◽

2019 ◽

Vol 99 ◽

pp. 106595

Author(s):

Linda Starnes ◽

Andrew Hall ◽

Anna-Lina Cavallo ◽

Damla Etal ◽

Shailesh Gupta ◽

...

Keyword(s):

Genetic Variability ◽

Calcium Handling ◽

Cardiovascular Safety ◽

Drug Induced ◽

Patient Centric

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In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity

Fundamental and Clinical Pharmacology ◽

10.1046/j.1472-8206.2002.00081.x ◽

2002 ◽

Vol 16 (2) ◽

pp. 125-140 ◽

Author(s):

Fred De Clerck ◽

Andre Van de Water ◽

Jan D'Aubioul ◽

Hua Rong Lu ◽

Koen van Rossem ◽

...

Keyword(s):

Qt Prolongation ◽

Chemical Entity ◽

Cardiovascular Safety ◽

Safety Pharmacology ◽

In Vivo Measurement ◽

New Chemical Entity

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Comparison of freely-moving telemetry Chinese Miniature Experiment Pigs (CMEPs) to beagle dogs in cardiovascular safety pharmacology studies

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2014.03.172 ◽

2014 ◽

Vol 70 (1) ◽

pp. 19-28 ◽

Author(s):

Haitao Yuan ◽

Jing Zhao ◽

Jiabin Guo ◽

Ruiqin Wu ◽

Li He ◽

...

Keyword(s):

Cardiovascular Safety ◽

Beagle Dogs ◽

Safety Pharmacology ◽

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Cardiovascular Safety Pharmacology Issue Resolution

Advanced Issue Resolution in Safety Pharmacology ◽

10.1016/b978-0-12-812206-8.00013-3 ◽

2019 ◽

pp. 267-285

Author(s):

Annie Delaunois ◽

Marie-Luce Rosseels ◽

Jean-Pierre Valentin

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology

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Statistical considerations on the power of cardiovascular safety pharmacology studies

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2010.11.090 ◽

2010 ◽

Vol 62 (2) ◽

pp. e26-e27

Author(s):

Dingzhou Dean Li

Keyword(s):

Cardiovascular Safety ◽

Safety Pharmacology

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