The Role of Salivary Pepsin in the Diagnosis of Gastroesophageal Reflux Disease (GERD) Evaluated Using High-Resolution Manometry and 24-Hour Multichannel Intraluminal Impedance-pH Monitoring

ABSTRACT Background - Gastroesophageal reflux disease is the most common esophageal disorder in pediatrics. Objective - The aim of this study was to compare reflux parameters of typical and atypical symptoms of gastroesophageal reflux disease using 24-hour esophageal pH monitoring and multichannel intraluminal impedance in pediatric population. Methods - In this prospective study, 43 patients aged less than 18 year with suspected gastroesophageal reflux disease were enrolled. The patients were divided into two groups based on the main presenting symptoms (typical versus atypical). Twenty four-hour pH monitoring and multichannel intraluminal impedance were performed in all the patients for comparing these two group regarding association of symptoms and reflux. Number of refluxes, pH related reflux, total reflux time, reflux more than 5 minutes, longest time of the reflux, lowest pH at reflux, reflux index were recorded and compared. Data comparison was done using SPSS. Results - The mean age of the patients was 5.7±3.4 years and 65.1% were male. Out of 43 patients 24 cases had typical symptoms and 19 had atypical symptoms. The mean reflux events detected by multichannel intraluminal impedance was more than mean reflux events detected by pH monitoring (308.4±115.8 vs 69.7±66.6) with P value of 0.037, which is statistically significant. The mean symptom index and symptom association probability were 35.01% ± 20.78% and 86.42% ± 25.79%, respectively in multichannel intraluminal impedance versus 12.73% ± 12.48% and 45.16% ± 42.29% in pH monitoring (P value <0.001). Number of acid reflux was 46.26±47.16 and 30.9±22.09 for atypical and typical symptoms respectively. The mean symptom index was 18.12% ± 13.101% and 8.30% ± 10.301% in atypical and typical symptoms respectively (P=0.034). Bolus clearance was longer in atypical symptoms compared typical symptoms(P<0.05). Conclusion - Symptom index was significantly higher in atypical symptoms compared to typical symptoms. Higher number of acid reflux was found in children with atypical symptoms of reflux. Longer duration of bolus clearance was found in group with atypical symptoms of reflux.

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The role of combined multichannel intraluminal impedance and pH-monitoring in newborn with gastroesophageal reflux disease

Reviews in Health Care ◽

10.7175/rhc.v1i1.16 ◽

2010 ◽

Vol 1 (1) ◽

pp. 35-52

Author(s):

Francesco Cresi ◽

Emanuela Locatelli

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Ph Monitoring ◽

Body Position ◽

Respiratory Events ◽

Intraluminal Impedance ◽

Analyse Data ◽

Neonates And Infants

Gastroesophageal reflux disease (GERD) is a relevant problem in first months of life and its early diagnosis and its appropriate therapy represent a real challenge for neonatologists.Multichannel Intraluminal Impedance associated with esophageal pH-monitoring (MII/pH) has been recently introduced to study GERD in infants. This technique, which is safe and with a good compliance, presents an elevated accuracy in identifying refluxes independently from their pH. The main aim of this review is to analyse data in literature on the use of MII/pH in neonates.We have considered recent studies published in PubMed in which MII is used in neonates and infants with GER: 26 studies focus on GER physiopathology and on the advantages of using MII in addition to pH-monitoring, 13 on symptoms associated with refluxes (in particular cardio-respiratory events and apnoeas) and 13 on therapy (5 on body position, 3 on thickened formulas, 1 on fortified milk and 4 on drugs).We underline the role of MII/pH in studying GERD in neonates, in which non acid-refluxes result prevalent, because of the buffering effects of milk, and in which the majority of symptoms arerelated to non-acid or weakly-acid GER. MII/pH can be considered a good technique even in the evaluation of the temporal relation between refluxes and symptoms and in the analysis of the benefits obtained by pharmacological and non-pharmacological therapy.The increasing application of MII/pH can help neonatologists to comprehend GER physiopathology, to diagnose GER and GERD and to treat better its symptoms in first months of life.

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