Effect of Vitamin B6Deficiency on Linoleic Acid Desaturation in the Arachidonic Acid Biosynthesis of Rat Liver Microsomes

1994 ◽  
Vol 58 (3) ◽  
pp. 459-463 ◽  
Author(s):  
Qing-Bai She ◽  
Takashi Hayakawa ◽  
Haruhito Tsuge
Keyword(s):  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Acid Biosynthesis

scholarly journals Effect of dietary fats on the δ6- and δ5-desaturation of fatty acids in rat liver microsomes

1983 ◽  
Vol 50 (3) ◽  
pp. 749-756 ◽  
Author(s):  
D. Kirstein ◽  
C.-E. Høy ◽  
G. Hølmer
Keyword(s):  
Arachidonic Acid ◽  
Linolenic Acid ◽  
Rat Liver ◽  
Desaturase Activity ◽  
Liver Microsomes ◽  
Dietary Fats ◽  
Rat Liver Microsomes ◽  
Δ5 Desaturase ◽  
Substrate Level

1. Rats were given diets containing (% dietary energy): 46 arachis oil (AO), 36 partially-hydrogenated arachis oil (HAO) + 10 AO, 36 partially-hydrogenated marine oil (HMO) + 10 AO, or 46 of a combination of rape-seed oils high and low in erucic acid (RSO + LERSO).2. In the liver microsomes the content of arachidonic acid (20:4ω6) was reduced inthe groups given HAO + AO and HMO + AO.3. The rates of Δ6-desaturation of linoleic acid into γ-linolenic acid (18:3ω6) and of Δ5-desaturation of dihomo-γ-linolenic acid into arachidonic acid were studied in vitro at two substrate levels: a high substrate level reflecting maximal microsomal desaturase activity in rat liver and a low substrate level reflecting desaturase activity under physiological conditions.4. Dietary HAO, rich in 18:1 isomers, suppressed the Δ6-desaturase activity butnot the Δ5-desaturase activity. Dietary HMO, rich in 18:1, 20:1 and 22:1 isomers, reduced both Δ6- and Δ5-desaturase activities.

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