scholarly journals Hard-To-Treat Idiopathic Refractory Autoimmune Haemolytic Anaemia with Reticulocytopenia

2020 ◽  
Author(s):  
Marcelo Aveiro ◽  
Gisela Ferreira ◽  
Carla Matias ◽  
Ana Oliveira ◽  
Tatiana Rodrigues
Keyword(s):  
Haemolytic Anaemia ◽  
Great Majority ◽  
Therapeutic Options ◽  
Autoimmune Haemolytic Anaemia ◽  
Rare Presentation ◽  
Prednisolone Dose ◽  
Epoetin Beta ◽  
Poor Outcome ◽  
Great Severity ◽  
Uncommon Condition

Autoimmune haemolytic anaemia (AIHA) is an uncommon condition characterized by increased destruction of erythrocytes associated with reticulocytosis in the great majority of cases. We present the case of a 68-year-old woman with jaundice and malaise. Investigation revealed AIHA with reticulocytopenia. The patient failed to respond to prednisolone or to rituximab. Azathioprine and epoetin beta were subsequently started, the prednisolone dose was increased, and the patient began to respond after 1 month. In AIHA, reticulocytopenia is a very rare presentation and a sign of great severity and poor outcome. The scarcity of therapeutic options in refractory cases poses a major challenge for physicians.  

scholarly journals Epidemiology of Secondary Warm Autoimmune Haemolytic Anaemia—A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (6) ◽  
pp. 1244
Author(s):  
Stinne Tranekær ◽  
Dennis Lund Hansen ◽  
Henrik Frederiksen
Keyword(s):  
Haemolytic Anaemia ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Underlying Disease ◽  
Age At Diagnosis ◽  
Autoimmune Haemolytic Anaemia ◽  
Sex Distribution ◽  
Number Of Patients ◽  
Study Results ◽  
Full Text Review

Background: Warm autoimmune haemolytic anaemia (wAIHA) is a haemolytic disorder, most commonly seen among adults and is classified as either primary or secondary to an underlying disease. We describe the age and sex distribution and the proportion of secondary wAIHA. Method: We retrieved 2635 published articles, screened abstracts and titles, and identified 27 articles eligible for full-text review. From these studies, we extracted data regarding number of patients, sex distribution, age at diagnosis, number of patients with secondary wAIHA, and whether the patients were diagnosed through local or referral centres. All data were weighted according to the number of included patients in each study. Results: 27 studies including a total of 4311 patients with wAIHA, of which 66% were females, were included. The median age at diagnosis was 68.7 years, however, wAIHA affected all ages. The mean proportion of secondary wAIHA was 49%, most frequently secondary to systemic lupus erythematosus. The proportions of secondary wAIHA reported from primary vs. referral centres were 35% vs. 59%, respectively. Conclusion: This review consolidates previously reported gender distribution. The higher proportion of secondary wAIHA in referral centres suggests that the most severely affected patients are disproportionally more frequent in such facilities.

Autoimmune haemolytic anaemia associated with transitional cell carcinoma

The Lancet ◽  
1992 ◽  
Vol 340 (8815) ◽  
pp. 373 ◽  
Author(s):  
Seikei Hibino ◽  
RonaldG. Stoller ◽  
SamuelA. Jacobs
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Haemolytic Anaemia ◽  
Transitional Cell ◽  
Autoimmune Haemolytic Anaemia
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