scholarly journals Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81633 ◽  
Author(s):  
Sabine Groenke ◽  
Eric D. Larson ◽  
Sarah Alber ◽  
Rui Zhang ◽  
Scott T. Lamp ◽  
...  
Keyword(s):  
Sinoatrial Node ◽  
Pacemaker Activity ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

scholarly journals Atrial-Specific NCX KO Mice Reveal Dependence of Sinoatrial Node Pacemaker Activity on Sodium-Calcium Exchange

2012 ◽  
Vol 102 (3) ◽  
pp. 663a ◽  
Author(s):  
Sabine Groenke ◽  
Eric D. Larson ◽  
Haruko Nakano ◽  
Atsushi Nakano ◽  
Catherine Proenza ◽  
...  
Keyword(s):  
Sinoatrial Node ◽  
Pacemaker Activity ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

scholarly journals Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Arie O. Verkerk ◽  
Marcel M. G. J. van Borren ◽  
Ronald Wilders
Keyword(s):  
Cardiac Electrophysiology ◽  
Sinoatrial Node ◽  
Calcium Transient ◽  
Membrane Current ◽  
Exchange Current ◽  
Pacemaker Activity ◽  
Pacemaker Cells ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

There is an ongoing debate on the mechanism underlying the pacemaker activity of sinoatrial node (SAN) cells, focusing on the relative importance of the “membrane clock” and the “Ca2+clock” in the generation of the small net membrane current that depolarizes the cell towards the action potential threshold. Specifically, the debate centers around the question whether the membrane clock-driven hyperpolarization-activated current,If, which is also known as the “funny current” or “pacemaker current,” or the Ca2+clock-driven sodium-calcium exchange current,INaCa, is the main contributor to diastolic depolarization. In our contribution to this journal’s “Special Issue on Cardiac Electrophysiology,” we present a numerical reconstruction ofIfandINaCain isolated rabbit and human SAN pacemaker cells based on experimental data on action potentials,If, and intracellular calcium concentration ([Ca2+]i) that we have acquired from these cells. The human SAN pacemaker cells have a smallerIf, a weaker[Ca2+]itransient, and a smallerINaCathan the rabbit cells. However, when compared to the diastolic net membrane current,INaCais of similar size in human and rabbit SAN pacemaker cells, whereasIfis smaller in human than in rabbit cells.

Cellular Regulation of Sodium-Calcium Exchange

2006 ◽  
Vol 976 (1) ◽  
pp. 214-223 ◽  
Author(s):  
MADALINA CONDRESCU ◽  
KWABENA OPUNI ◽  
BASIL M. HANTASH ◽  
JOHN P. REEVES
Keyword(s):  
Cellular Regulation ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 1. Mechanism of inhibition by amiloride analogs

Biochemistry ◽  
1988 ◽  
Vol 27 (7) ◽  
pp. 2403-2409 ◽  
Author(s):  
Robert S. Slaughter ◽  
Maria L. Garcia ◽  
Edward J. Cragoe ◽  
John P. Reeves ◽  
Gregory J. Kaczorowski
Keyword(s):  
Membrane Vesicles ◽  
Sarcolemmal Membrane ◽  
Sodium Calcium ◽  
Mechanism Of Inhibition ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange ◽  
Amiloride Analogs

Potassium-Calcium and Sodium-Calcium Exchange on Kaolinite and Kaolinitic Soils

1988 ◽  
Vol 52 (5) ◽  
pp. 1259-1264 ◽  
Author(s):  
G. J. Levy ◽  
H. v. H. van der Watt ◽  
I. Shainberg ◽  
H. M. du Plessis
Keyword(s):  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

Inhibitors of sodium-calcium exchange: identification and development of probes of transport activity

1989 ◽  
Vol 988 (2) ◽  
pp. 287-302 ◽  
Author(s):  
Gregory J. Kaczorowski ◽  
Robert S. Slaughter ◽  
V. Frank King ◽  
María L. Garcia
Keyword(s):  
Transport Activity ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange
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