scholarly journals Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235483
Author(s):  
Huiyu Zhou ◽  
Mei Zhu ◽  
Ling Ma ◽  
Jinming Zhou ◽  
Biao Dong ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Docking Study ◽  
Biological Evaluation ◽  
The Novel ◽  
Design Synthesis ◽  
Hiv 1

scholarly journals Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

2017 ◽  
Vol 27 (21) ◽  
pp. 4925-4931 ◽  
Author(s):  
Arun K. Ghosh ◽  
W. Sean Fyvie ◽  
Margherita Brindisi ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation

2016 ◽  
Vol 59 (14) ◽  
pp. 6826-6837 ◽  
Author(s):  
Arun K. Ghosh ◽  
Heather L. Osswald ◽  
Kristof Glauninger ◽  
Johnson Agniswamy ◽  
Yuan-Fang Wang ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Protein X ◽  
Hiv 1

scholarly journals Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

2015 ◽  
Vol 25 (21) ◽  
pp. 4903-4909 ◽  
Author(s):  
Arun K. Ghosh ◽  
Jun Takayama ◽  
Luke A. Kassekert ◽  
Jean-Rene Ella-Menye ◽  
Sofiya Yashchuk ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

2015 ◽  
Vol 13 (48) ◽  
pp. 11607-11621 ◽  
Author(s):  
Arun K. Ghosh ◽  
Cuthbert D. Martyr ◽  
Luke A. Kassekert ◽  
Prasanth R. Nyalapatla ◽  
Melinda Steffey ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed and synthesized.

scholarly journals Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir

ChemMedChem ◽  
2017 ◽  
Vol 12 (23) ◽  
pp. 1942-1952 ◽  
Author(s):  
Arun K. Ghosh ◽  
W. Sean Fyvie ◽  
Margherita Brindisi ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

Structure-Based Design:  Synthesis and Biological Evaluation of a Series of Novel Cycloamide-Derived HIV-1 Protease Inhibitors

2005 ◽  
Vol 48 (10) ◽  
pp. 3576-3585 ◽  
Author(s):  
Arun K. Ghosh ◽  
Lisa M. Swanson ◽  
Hanna Cho ◽  
Sofiya Leshchenko ◽  
Khaja Azhar Hussain ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors

2003 ◽  
Vol 46 (10) ◽  
pp. 1831-1844 ◽  
Author(s):  
Amos B. Smith ◽  
Louis-David Cantin ◽  
Alexander Pasternak ◽  
Lisa Guise-Zawacki ◽  
Wenquin Yao ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2′ side chains

2006 ◽  
Vol 16 (4) ◽  
pp. 859-863 ◽  
Author(s):  
Amos B. Smith ◽  
Adam K. Charnley ◽  
Hironori Harada ◽  
Jason J. Beiger ◽  
Louis-David Cantin ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Side Chains ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1
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