scholarly journals AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis

2012 ◽  
Vol 8 (4) ◽  
pp. e1002661 ◽  
Author(s):  
Theresa S. Moser ◽  
Daniel Schieffer ◽  
Sara Cherry
Keyword(s):  
Fatty Acid ◽  
Virus Infection ◽  
Fatty Acid Synthesis ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Acid Synthesis ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection

2018 ◽  
Vol 218 (11) ◽  
pp. 1847-1851 ◽  
Author(s):  
Anita K McElroy ◽  
Jessica R Harmon ◽  
Timothy Flietstra ◽  
Stuart T Nichol ◽  
Christina F Spiropoulou
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

Serological evidence of Rift Valley fever virus infection in slaughtered ruminants in Nigeria

2019 ◽  
Vol 40 (4) ◽  
pp. 367-377 ◽  
Author(s):  
Adewale Victor Opayele ◽  
Linda Amarachi Ndiana ◽  
Georgina Njideka Odaibo ◽  
David Olufemi Olaleye
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Serological Evidence ◽  
Valley Fever

Protection against Rift Valley fever virus infection in mice upon administration of interferon-inducing RNA transcripts from the FMDV genome

2014 ◽  
Vol 109 ◽  
pp. 64-67 ◽  
Author(s):  
Gema Lorenzo ◽  
Miguel Rodríguez-Pulido ◽  
Elena López-Gil ◽  
Francisco Sobrino ◽  
Belén Borrego ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Rna Transcripts

scholarly journals Wolbachia effects on Rift Valley fever virus infection in Culex tarsalis mosquitoes

2017 ◽  
Vol 11 (10) ◽  
pp. e0006050 ◽  
Author(s):  
Brittany L. Dodson ◽  
Elizabeth S. Andrews ◽  
Michael J. Turell ◽  
Jason L. Rasgon
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Culex Tarsalis ◽  
Valley Fever

scholarly journals Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

2012 ◽  
Vol 6 (2) ◽  
pp. e1529 ◽  
Author(s):  
Kimberly K. Gray ◽  
Melissa N. Worthy ◽  
Terry L. Juelich ◽  
Stacy L. Agar ◽  
Allison Poussard ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Inflammatory Responses ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

Animal models of Rift Valley fever virus infection

2012 ◽  
Vol 163 (2) ◽  
pp. 417-423 ◽  
Author(s):  
Ted M. Ross ◽  
Nitin Bhardwaj ◽  
Stephanie J. Bissel ◽  
Amy L. Hartman ◽  
Darci R. Smith
Keyword(s):  
Animal Models ◽  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Virion-associated spermidine transmits with Rift Valley fever virus particles to maintain infectivity

2020 ◽  
Author(s):  
Vincent Mastrodomenico ◽  
Jeremy J. Esin ◽  
Shefah Qazi ◽  
Oreoluwa S. Omoba ◽  
Brittany L. Fung ◽  
...  
Keyword(s):  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rna Virus ◽  
Rift Valley Fever Virus ◽  
Acid Synthesis ◽  
Fever Virus ◽  
Virus Infectivity ◽  
Cellular Functions ◽  
Valley Fever

AbstractViruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules is diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively-charged molecules involved in cell cycle, translation, and nucleic acid synthesis, among other cellular functions. Polyamines also support replication of diverse viruses, and they are important for processes such as transcription, translation, and viral protein enzymatic activity. Rift Valley fever virus (RVFV) is a negative-sense RNA virus that requires polyamines to produce infectious particles. In polyamine depleted conditions, noninfectious particles are produced that interfere with virus replication and stimulate immune signaling. Here, we find that RVFV relies on virion-associated polyamines to maintain infectivity. We show that RVFV replication is facilitated by any of the three biogenic polyamines; however, we specifically find spermidine associated with purified virions. Using a panel of polyamine homologs, we observe that virions can also associate with (R)-3-methylspermidine and norspermidine, though not with other less homologous molecules. Using polyamine reporter cells, we demonstrate that virion-associated polyamines transmit from one infected cell to another. Finally, we find that virions devoid of polyamines are unstable and cannot be supplemented with exogenous polyamines to regain stability or infectivity. These data highlight a unique role for polyamines, and spermidine in particular, in maintaining virus infectivity, a function not previously appreciated. Further, these studies are the first to identify polyamines associated with RVFV virions. Targeting polyamines represents a promising antiviral strategy, and this work highlights a new mechanism by which we can inhibit virus replication through FDA-approved polyamine depleting pharmaceuticals.

scholarly journals Presence of Viral RNA and Proteins in Exosomes from Cellular Clones Resistant to Rift Valley Fever Virus Infection

2016 ◽  
Vol 7 ◽  
Author(s):  
Noor A. Ahsan ◽  
Gavin C. Sampey ◽  
Ben Lepene ◽  
Yao Akpamagbo ◽  
Robert A. Barclay ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Viral Rna ◽  
Valley Fever
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