scholarly journals The Intersection of Cultural Characteristics and Genetics on the Prevalence of Delayed Sleep Phase Syndrome in Brazilian and Japanese Adults

2020 ◽  
Vol 1 (4) ◽  
pp. 1-6
Author(s):  
Abram Estafanous ◽  
Karim Sedky
Keyword(s):  
Circadian Rhythm ◽  
Environmental Changes ◽  
Clock Genes ◽  
Cultural Characteristics ◽  
Sleep Phase ◽  
Delayed Sleep Phase Syndrome ◽  
Japanese Adults ◽  
Delayed Sleep Phase ◽  
Rhythm Disorder ◽  
Delayed Sleep

Delayed sleep phase syndrome (DSPS) is a circadian rhythm disorder where individuals experience difficulty modifying the time they go to sleep and wake up in response to environmental changes. The circadian rhythm itself is regulated by a variety of clock genes, and various other genes (e.g., AA-NAT gene, CKIϵ gene) code for proteins that regulate clock genes. Various polymorphisms of the clock gene influencers have been shown to increase susceptibility to DSPS. This paper seeks to examine how certain cultural characteristics (e.g., napping, timing of meals, exposure to artificial light) and the presence of the AA-NAT gene (G619A polymorphism) and the CKIϵ gene (S408N polymorphism) influence the prevalence of DSPS amongst Japanese and Brazilian populations.

scholarly journals Sleep and Circadian Rhythm Disturbances in Patients with Delayed Sleep Phase Syndrome

SLEEP ◽  
2003 ◽  
Vol 26 (6) ◽  
pp. 657-661 ◽  
Author(s):  
Tsuyoshi Watanabe ◽  
Naofumi Kajimura ◽  
Masaaki Kato ◽  
Masanori Sekimoto ◽  
Toru Nakajima ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sleep Phase ◽  
Delayed Sleep Phase Syndrome ◽  
Delayed Sleep Phase ◽  
Delayed Sleep

Chronobiological issues of sleep and circadian rhythms

2011 ◽  
Vol 26 (S2) ◽  
pp. 2133-2133
Author(s):  
G. Hajak
Keyword(s):  
Circadian Rhythm ◽  
Clock Genes ◽  
Phase Relationship ◽  
Temporal Organization ◽  
Stable Phase ◽  
Delayed Sleep Phase Syndrome ◽  
Circadian Rhythm Sleep Disorders ◽  
Delayed Sleep Phase ◽  
Circadian Clock Genes ◽  
Delayed Sleep

Progress in unravelling the cellular and molecular basis of mammalian circadian regulation over the past decade has provided us with data that deteriorations in measurable circadian output parameters, such as sleep/wake deficits and dysregulation of circulating hormone levels, are common features of most central nervous system disorders.At the core of the mammalian circadian system is a complex of molecular oscillations within the hypothalamic suprachiasmatic nucleus. These oscillations are modifiable by afferent signals from the environment, and integrated signals are subsequently conveyed to remote central neural circuits where specific output rhythms are regulated. Usually our sleep/wake cycle, temperature and melatonin rhythms are internally synchronized with a stable phase relationship. When there is a desynchrony between the sleep/wake cycle and circadian rhythm, sleep disorders such as advanced and delayed sleep phase syndrome can arise as well as transient chronobiologic disturbances, for example from jet lag and shift work.Increasing evidence suggests that disrupted temporal organization of biological functions impairs behaviour, cognition, affect, and emotion. Furthermore, disruption of circadian clock genes impairs the sleep-wake cycle and social rhythms, which may be implicated in particular in mental disorders. An increasing number of journal publications point to a crucial role of circadian rhythm dysregulations in particular for affective disorders, which should e addressed specifically in modern psychiatry.

scholarly journals Moléculas que marcam o tempo: implicações para os fenótipos circadianos

2009 ◽  
Vol 31 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Danyella Silva Pereira ◽  
Sergio Tufik ◽  
Mario Pedrazzoli
Keyword(s):  
Circadian Rhythms ◽  
Mood Disorder ◽  
Clock Genes ◽  
Jet Lag ◽  
Sleep Phase ◽  
Delayed Sleep Phase Syndrome ◽  
Diurnal Preference ◽  
Delayed Sleep Phase ◽  
Delayed Sleep

OBJETIVO: Revisar resumidamente a literatura dos últimos 36 anos de pesquisa em cronobiologia molecular a fim de informar aos profissionais de saúde os avanços obtidos nesta área e os potenciais para aplicação na clínica médica. MÉTODO: Buscas na literatura foram realizadas utilizando as bases de dados PubMed e Scopus usando como palavras-chave "clock genes, circadian rhythms, diurnal preference, delayed sleep phase syndrome, advanced sleep phase syndrome, photoperiod and mood disorder". DISCUSSÃO: Atualmente, o mecanismo molecular da regulação da ritmicidade circadiana é compreendido em grande detalhe. Muitos estudos publicados mostram associações de polimorfismos nos genes relógio com transtornos do ritmo circadiano e com transtornos do humor. CONCLUSÕES: De maneira geral, o progresso obtido na área de cronobiologia molecular traz um melhor entendimento da regulação do sistema de temporização biológico. O desenvolvimento de estudos nesta área tem o potencial de ser aplicável ao tratamento dos transtornos dos ritmos circadianos e certos transtornos do humor, além de prevenir riscos à saúde causados por viagens intercontinentais (Jet Lag) e por trabalhos noturnos e por turnos.

Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome

2009 ◽  
Vol 10 (5) ◽  
pp. 549-555 ◽  
Author(s):  
Shadab A. Rahman ◽  
Leonid Kayumov ◽  
Ekaterina A. Tchmoutina ◽  
Colin M. Shapiro
Keyword(s):  
Clinical Efficacy ◽  
Sleep Phase ◽  
Dim Light Melatonin Onset ◽  
Delayed Sleep Phase Syndrome ◽  
Delayed Sleep Phase ◽  
Dim Light ◽  
Delayed Sleep
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