AbstractDownstream processing in industrial biotechnology is a very important part of the overall bioproduct manufacturing. Sometimes the cost for this part of biotechnologies is up to 50% of the overall expenses. It comprises product concentration, separation and purification to different extents, as requested. The usually low product concentrations, the large volumes of fermentation broth and the product sensitivity toward higher temperatures lead to specific methods, similar but not identical to the ones in traditional chemical technology.This article summarizes briefly the unit operations in downstream processing in industrial biotechnology, making a parallel between biotechnology and chemical technology.
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