scholarly journals Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula

eNeuro ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. ENEURO.0197-20.2020 ◽  
Author(s):  
Xiao-Tao Jin ◽  
Brenton R. Tucker ◽  
Ryan M. Drenan
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration ◽  
Medial Habenula ◽  
Plastic Changes

scholarly journals Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration

2021 ◽  
Author(s):  
Elizabeth A Souter ◽  
Yen-Chu Chen ◽  
Vivien Zell ◽  
Valeria Lallai ◽  
Thomas Steinkellner ◽  
...  
Keyword(s):  
Cholinergic Neurons ◽  
Nicotine Addiction ◽  
Conditional Knockout ◽  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula ◽  
Field Assay ◽  
Nicotine Consumption ◽  
Additional Support ◽  
Cholinergic Projections

Cholinergic projections from the medial habenula (MHb) to the interpeduncular nucleus (IPN) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawal. While it has been established that MHb cholinergic projections co-release glutamate, no direct evidence has demonstrated a role for this specific glutamate projection in nicotine consumption. In the present study, a novel floxed Slc17a7 (VGLUT1) mouse was generated and used to create conditional knockout (cKO) mice that lack VGLUT1 in MHb cholinergic neurons. Histochemical approaches and optogenetics-assisted electrophysiology were used to validate the disruption of VGLUT1 from cholinergic MHb to IPN projections. The mice displayed no gross phenotypic abnormalities and exhibited normal exploratory and locomotor behavior in the open-field assay. However, the loss of VGLUT1-mediated glutamate co-release led to increased nicotine self-administration. These findings indicate that glutamate co-release from ventral MHb cholinergic neurons opposes nicotine consumption and provide additional support for targeting this synapse to develop potential treatments to nicotine addiction.

Role of α4- and α6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration

2014 ◽  
Vol 20 (3) ◽  
pp. 500-512 ◽  
Author(s):  
Heather B. Madsen ◽  
Harcharan S. Koghar ◽  
Tine Pooters ◽  
Jim S. Massalas ◽  
John Drago ◽  
...  
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration

Antagonism of α3β4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration

2002 ◽  
Vol 438 (1-2) ◽  
pp. 99-105 ◽  
Author(s):  
Stanley D Glick ◽  
Isabelle M Maisonneuve ◽  
Barbara A Kitchen ◽  
Mark W Fleck
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration

18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats

2006 ◽  
Vol 537 (1-3) ◽  
pp. 94-98 ◽  
Author(s):  
Stanley D. Glick ◽  
Ruby L. Ramirez ◽  
Jacklyn M. Livi ◽  
Isabelle M. Maisonneuve
Keyword(s):  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula

Involvement of Nicotinic Receptors in Alcohol Self-Administration

2000 ◽  
Vol 24 (2) ◽  
pp. 155-163 ◽  
Author(s):  
A. D. Le ◽  
W. A. Corrigall ◽  
J. Watchus ◽  
S. Harding ◽  
W. Juzytsch ◽  
...  
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration

Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats

2021 ◽  
pp. 113574
Author(s):  
Edward D. Levin ◽  
Corinne Wells ◽  
Susan Slade ◽  
Joshua Johnson ◽  
Ann Petro ◽  
...  
Keyword(s):  
Self Administration ◽  
Medial Habenula

α3β4 subunit-containing nicotinic receptors dominate function in rat medial habenula neurons

1999 ◽  
Vol 38 (6) ◽  
pp. 769-783 ◽  
Author(s):  
Michael W. Quick ◽  
R.Michael Ceballos ◽  
Michael Kasten ◽  
J.Michael McIntosh ◽  
Robin A.J. Lester
Keyword(s):  
Nicotinic Receptors ◽  
Medial Habenula
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