Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats

2021 ◽  
pp. 113574
Author(s):  
Edward D. Levin ◽  
Corinne Wells ◽  
Susan Slade ◽  
Joshua Johnson ◽  
Ann Petro ◽  
...  
Keyword(s):  
Self Administration ◽  
Medial Habenula

scholarly journals Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration

2021 ◽  
Author(s):  
Elizabeth A Souter ◽  
Yen-Chu Chen ◽  
Vivien Zell ◽  
Valeria Lallai ◽  
Thomas Steinkellner ◽  
...  
Keyword(s):  
Cholinergic Neurons ◽  
Nicotine Addiction ◽  
Conditional Knockout ◽  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula ◽  
Field Assay ◽  
Nicotine Consumption ◽  
Additional Support ◽  
Cholinergic Projections

Cholinergic projections from the medial habenula (MHb) to the interpeduncular nucleus (IPN) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawal. While it has been established that MHb cholinergic projections co-release glutamate, no direct evidence has demonstrated a role for this specific glutamate projection in nicotine consumption. In the present study, a novel floxed Slc17a7 (VGLUT1) mouse was generated and used to create conditional knockout (cKO) mice that lack VGLUT1 in MHb cholinergic neurons. Histochemical approaches and optogenetics-assisted electrophysiology were used to validate the disruption of VGLUT1 from cholinergic MHb to IPN projections. The mice displayed no gross phenotypic abnormalities and exhibited normal exploratory and locomotor behavior in the open-field assay. However, the loss of VGLUT1-mediated glutamate co-release led to increased nicotine self-administration. These findings indicate that glutamate co-release from ventral MHb cholinergic neurons opposes nicotine consumption and provide additional support for targeting this synapse to develop potential treatments to nicotine addiction.

18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats

2006 ◽  
Vol 537 (1-3) ◽  
pp. 94-98 ◽  
Author(s):  
Stanley D. Glick ◽  
Ruby L. Ramirez ◽  
Jacklyn M. Livi ◽  
Isabelle M. Maisonneuve
Keyword(s):  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula

scholarly journals Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula

eNeuro ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. ENEURO.0197-20.2020 ◽  
Author(s):  
Xiao-Tao Jin ◽  
Brenton R. Tucker ◽  
Ryan M. Drenan
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration ◽  
Medial Habenula ◽  
Plastic Changes

scholarly journals Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration

eNeuro ◽  
2021 ◽  
pp. ENEURO.0481-21.2021
Author(s):  
Elizabeth A. Souter ◽  
Yen-Chu Chen ◽  
Vivien Zell ◽  
Valeria Lallai ◽  
Thomas Steinkellner ◽  
...  
Keyword(s):  
Self Administration ◽  
Medial Habenula

Author response for "Nectin‐2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula"

2020 ◽  
Author(s):  
Hajime Shiotani ◽  
Muneaki Miyata ◽  
Takeshi Kameyama ◽  
Kenji Mandai ◽  
Miwako Yamasaki ◽  
...  
Keyword(s):  
Synapse Formation ◽  
Cholinergic Neuron ◽  
Author Response ◽  
Medial Habenula

Collection of Ego-Centered Network Data with Computer-Assisted Interviews

Methodology ◽  
2006 ◽  
Vol 2 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Joachim Gerich ◽  
Roland Lehner
Keyword(s):  
Survey Methods ◽  
A Priori ◽  
Dynamic Structure ◽  
Computer Assisted ◽  
Network Data ◽  
Great Effort ◽  
Self Administration ◽  
Face To Face ◽  
Full Network

Although ego-centered network data provide information that is limited in various ways as compared with full network data, an ego-centered design can be used without the need for a priori and researcher-defined network borders. Moreover, ego-centered network data can be obtained with traditional survey methods. However, due to the dynamic structure of the questionnaires involved, a great effort is required on the part of either respondents (with self-administration) or interviewers (with face-to-face interviews). As an alternative, we will show the advantages of using CASI (computer-assisted self-administered interview) methods for the collection of ego-centered network data as applied in a study on the role of social networks in substance use among college students.

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