Case Report: Nicotine Addiction-Adolescence obsession

Nicotine dependence is a chronic relapse defined as a compulsive desire to use it, regardless of social consequences, loss of control over intake, and appearance of withdrawal symptoms. Nicotine dependence develops over time as a person continues to use nicotine. The most commonly used tobacco product is cigarettes, but any form of tobacco use and use of e-cigarettes can lead to dependence. Nicotine dependence is a serious public health problem because it causes continued tobacco use, which is one of the leading preventable causes of death worldwide, causing more than 8 million deaths per year. The result of the journal review is that preventing the use of tobacco products among adolescents is critical to ending nicotine addiction worldwide. The impact caused by nicotine tends to be bad, so stopping is the way out. Different levels of influence should be considered in interventions aimed at adolescent smokers, including psychological influences, addictions, peers and parents. This review article contains about the effect of nicotine on adolescents and what strategies can be done to stop the problem.

Assessment of Tobacco Dependence in Al-Bayda City, Libya

Tobacco is the second leading cause of the death in adults in the world today. This is because of tobacco dependence. Therefore, aim of this study is to assess the level of nicotine dependence through a small random group of smokers in the city of Al-Bayda using the Fagerstrom test for nicotine dependence and to know the extent of desire to quit and take action. The study included 150 male smokers, with an age group ranging between 18-60 years, in the period between February and June 2020 through a questionnaire containing six questions from the Fagerstrom test and collected smoking risks and presence of smoking cessation medications. Data were collected and statistically evaluated using chi-square. Most of the participants had a family history, they were smoking imitating brother, father and friends. The average number of cigarettes consumed was more than 31 cigarettes per day, with a 5-minute time difference being the highest. The rate of desire to smoke was observed in the morning hours more than others. The proportion was also high for those who were unable to stop in public even while ill. Most of them are aware of the existence of drugs that help in smoking cessation. As for the attempts to quit, there were attempts during different periods of time, most of which failed due to physical and social reasons. Most of the results indicate a high rate of dependence among smokers, for reasons that may be social and economic. Therefore, we need more data and a wider study area through health centers and try to understand the reasons for returning to smoking and treating them. work to validate reliability.

PHOSPHORYLATION OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II (CAMKII) AND EXTRACELLULAR REGULATED KINASE (ERK) IN STRIATUM MEDIATE NICOTINE DEPENDENCE IN BALB/C MICE

Objective: Nicotine is an active compound in tobacco and has a rewarding effect in the central nervous system (CNS), which may lead to dependence. Although nicotine dependence is elucidated by brain mechanisms, synaptic molecular substrates underlying the dependence remain unclear. We hypothesized that reward signaling is mediated by dopamine and glutamate receptors, in where calcium/calmodulin-dependent kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) may mediate the synaptic signaling of dependence. Methods: To investigate the roles of both CaMKII and ERK on nicotine dependence were assessed by conditioned place preference (CPP) methods followed by dissection. One day after conditioning, preference scores were measured to evaluate nicotine dependence. Mice were sacrificed and their striatum were dissected out for immunoblotting analyses of CaMKII and ERK phosphorylation. Results: Nicotine-induced conditioned place preference as a symptom of nicotine dependence. CaMKII and ERK phosphorylation in striatum significantly increased along with the development of nicotine dependence. Conclusion: We should next apply pharmacological strategies to manipulate CaMKII and ERK signaling. In particular, disruption of reconsolidation by disrupting CaMKII and ERK signaling may propose an attractive therapeutic approach to inhibit nicotine dependence.

Nicotine Dependence in Patients with Major Depressive Disorder and Psychotic Disorders and Its Relationship with Quality of Life

The aim of the current study was to examine the associations between nicotine dependence and quality of life (QOL) among individuals diagnosed with major depressive disorder (MDD) or psychotic disorders. Methods: A total of 378 participants diagnosed with either MDD or psychotic disorders were recruited. The Fagerstorm Test for Nicotine Dependence was used to measure the level of nicotine dependence. The SF-12 health survey questionnaire was used to measure the QOL. Results: The prevalence of nicotine dependence was 23.3% in this sample population. For those diagnosed with MDD, moderate level of nicotine dependence was negatively associated with Vitality and Mental Component Score. For those diagnosed with a psychotic disorder high nicotine dependence was negatively associated with Role Emotional, Mental Health and Mental Component Score. Discussion: Compared to the general population, the prevalence of smoking in this psychiatric population was 2.4 times higher, while that of nicotine dependence was seven times higher. Individuals with psychotic disorder generally reported better QOL as compared to individuals with MDD. QOL differed across diagnostic groups with regards to socio-demographics, such as age, ethnicity, marital status, education, employment status and monthly income. Among individuals with MDD and psychotic disorders, different levels of nicotine dependence resulted in different levels of association with QOL. More research is needed to better understand the differences in QOL among the varying levels of nicotine dependence.

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behavior. The endocannabinoid system, which has been reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also implicated in nicotine dependence. This review summarizes and updates the main behavioral and biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as well as in nicotine withdrawal and relapse to nicotine-seeking behavior. Promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.

Prepared and Reactive Inhibition in Smokers and Non-smokers

Models of addiction have identified deficits in inhibitory control, or the ability to inhibit inappropriate or unwanted behaviors, as one factor in the development and maintenance of addictive behaviors. Current literature supports disruption of the prefrontal circuits that mediate reactive inhibitory control processes (i.e. inhibition in response to sudden, unplanned changes in environmental demands) in substance use disorders, however, the relationship between disorders of addiction, such as nicotine dependence, and planned inhibitory processes is unclear. The goal of the present study was to examine the extent to which reactive and planned inhibitory processes are differentially disrupted in nicotine dependent individuals. To this aim, we employed a novel stop signal task that explicitly separates planned and reactive inhibitory processes and assessed (1) group differences in task performance between smokers and non- smokers and (2) the relationship between task performance and smoking behaviors within the smoking group. We found significant differences in stop times for both trial between groups as well as within groups. Analyses of stopping behavior in the smoking group revealed an inverse correlation between stop times on planned stop trials and a measure of nicotine dependence derived from the Fagerstrom Test of Nicotine Dependence and, surprisingly, showed that greater daily average consumption of nicotine was inversely related to stop times for both trial types. Finally, we found that recency of the last cigarette smoked was unrelated to stopping behavior.