18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats

2006 ◽  
Vol 537 (1-3) ◽  
pp. 94-98 ◽  
Author(s):  
Stanley D. Glick ◽  
Ruby L. Ramirez ◽  
Jacklyn M. Livi ◽  
Isabelle M. Maisonneuve
Keyword(s):  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula

scholarly journals Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration

2021 ◽  
Author(s):  
Elizabeth A Souter ◽  
Yen-Chu Chen ◽  
Vivien Zell ◽  
Valeria Lallai ◽  
Thomas Steinkellner ◽  
...  
Keyword(s):  
Cholinergic Neurons ◽  
Nicotine Addiction ◽  
Conditional Knockout ◽  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Medial Habenula ◽  
Field Assay ◽  
Nicotine Consumption ◽  
Additional Support ◽  
Cholinergic Projections

Cholinergic projections from the medial habenula (MHb) to the interpeduncular nucleus (IPN) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawal. While it has been established that MHb cholinergic projections co-release glutamate, no direct evidence has demonstrated a role for this specific glutamate projection in nicotine consumption. In the present study, a novel floxed Slc17a7 (VGLUT1) mouse was generated and used to create conditional knockout (cKO) mice that lack VGLUT1 in MHb cholinergic neurons. Histochemical approaches and optogenetics-assisted electrophysiology were used to validate the disruption of VGLUT1 from cholinergic MHb to IPN projections. The mice displayed no gross phenotypic abnormalities and exhibited normal exploratory and locomotor behavior in the open-field assay. However, the loss of VGLUT1-mediated glutamate co-release led to increased nicotine self-administration. These findings indicate that glutamate co-release from ventral MHb cholinergic neurons opposes nicotine consumption and provide additional support for targeting this synapse to develop potential treatments to nicotine addiction.

scholarly journals Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration

2022 ◽  
Author(s):  
Ryan Drenan ◽  
Xiao-Tao Jin ◽  
Brenton Tucker ◽  
Leanne Thomas ◽  
Noah Walker ◽  
...  
Keyword(s):  
Tobacco Consumption ◽  
Male Rats ◽  
Blood Levels ◽  
Self Administration ◽  
Interpeduncular Nucleus ◽  
Nicotine Intake ◽  
Positron Emission ◽  
Intermittent Access ◽  
Underlying Mechanisms ◽  
Incubation Of Craving

Many tobacco smokers consume nicotine intermittently, but the underlying mechanisms and neurobiological changes associated with intermittent nicotine intake are unclear. Understanding intermittent nicotine intake is a high priority, as it could promote therapeutic strategies to attenuate tobacco consumption. We examined nicotine intake behavior and neurobiological changes in male rats that were trained to self-administer nicotine during brief (5 min) trials interspersed with longer (15 min) drug-free periods. Rats readily adapted to intermittent access (IntA) SA following acquisition on a continuous access (ContA) schedule. Probabilistic analysis of IntA nicotine SA suggested reduced nicotine loading behavior compared to ContA, and nicotine pharmacokinetic modeling revealed that rats taking nicotine intermittently may have increased intake to maintain blood levels of nicotine that are comparable to ContA SA. After IntA nicotine SA, rats exhibited an increase in unreinforced responses for nicotine-associated cues (incubation of craving) and specific alterations in the striatal proteome after 7 days without nicotine. IntA nicotine SA also induced nAChR functional upregulation in the interpeduncular nucleus (IPN), and it enhanced nicotine binding in the brain as determined via [11C]nicotine positron emission tomography. Reducing the saliency of the cue conditions during the 5 min access periods attenuated nicotine intake, but incubation of craving was preserved. Together, these results indicate that IntA conditions promote nicotine SA and nicotine seeking after a nicotine-free period.

scholarly journals Fetal Medial Habenula Transplants: Innervation of the Rat Interpeduncular Nucleus

1989 ◽  
Vol 1 (2) ◽  
pp. 57-62
Author(s):  
Nicholas J. Lenn ◽  
P. John Seeley ◽  
Pauline M. Field ◽  
Geoffrey Raisman
Keyword(s):  
Colloidal Gold ◽  
Third Ventricle ◽  
Donor Age ◽  
Adult Rats ◽  
Interpeduncular Nucleus ◽  
The Third ◽  
Medial Dorsal ◽  
Medial Habenula ◽  
The Difference

The effects of donor age and site of placement on the survival of fetal medial habenula (MH) transplants into adult rats hosts were examined. The innervation of the interpeduncular nucleus (IPN) in such cases was also examined. Explants of MH consisting of the medial-dorsal lip of the third ventricle were heldin vitrofor 1—2 days. Colloidal gold conjugated to wheat germ agglutinin was added for the last 18 hours to label the cells. Four of 16 cases with E19 derived transplants contained donor neurons. Markedly larger transplants were present in 95% of 20 cases with E16 derived transplants. Sites in the ventral midbrain were successful, while limited or no survival occurred at sites more remote from IPN. Retrograde labeling of transplant neurons was present in each case studied with HRP injection into host IPN. Colloidal gold-labeled macrophages, some oriented capillaries and GFAP-positive processes marked the donor-host interface. In EM the interface was evident only by the difference in tissue elements in the transplant versus host. Numerous synapses of Gray types I and II were present in the transplant. Excellent survival of MH neurons, donor/host interfaces, innervation of IPN by the transplant and fine structure in and around the transplants, all suggest that such preparations are suitable for further experimental analysis of the habenulo-interpeduncular system.

Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats

2021 ◽  
pp. 113574
Author(s):  
Edward D. Levin ◽  
Corinne Wells ◽  
Susan Slade ◽  
Joshua Johnson ◽  
Ann Petro ◽  
...  
Keyword(s):  
Self Administration ◽  
Medial Habenula

scholarly journals Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula

eNeuro ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. ENEURO.0197-20.2020 ◽  
Author(s):  
Xiao-Tao Jin ◽  
Brenton R. Tucker ◽  
Ryan M. Drenan
Keyword(s):  
Nicotinic Receptors ◽  
Self Administration ◽  
Medial Habenula ◽  
Plastic Changes

The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma

2020 ◽  
Vol 19 (32) ◽  
pp. 2991-2998 ◽  
Author(s):  
Vladimir N. Nikolenko ◽  
Leonid A. Gridin ◽  
Marine V. Oganesyan ◽  
Negoriya A. Rizaeva ◽  
Yury S. Podolskiy ◽  
...  
Keyword(s):  
Point Of View ◽  
Interpeduncular Nucleus ◽  
Surgical Interventions ◽  
Medial Habenula ◽  
Mental Diseases ◽  
Different Types ◽  
Psychiatric Conditions ◽  
The Individual ◽  
Positive Results ◽  
Surgical Operations

Background: There is a dearth of published information on the posterior perforated substance as compared to the anterior perforated substance. We managed to glean facts about the posterior perforated substance that can serve as a landmark for surgical operations in the adjacent regions of the midbrain and the vessels passing through it. Moreover, the posterior perforated substance contains the interpeduncular nucleus responsible for the mental state of the individual. Objectives: 1) To describe the topography of the blood vessels supplying the posterior perforated substance area from the surgical point of view; 2) to investigate the functions of the interpeduncular nucleus. Methods: We assembled and analyzed results from source databases by Elsevier, NCBI MedLine, Scopus, Scholar. Google and Embase. Each article was studied in detail for practically useful information about the posterior perforated substance. Results: The P1-segment perforating branches of the posterior cerebral artery supply the posterior perforated substance. This area is especially vulnerable in the case of vascular pathologies. The posterior communicating artery can block the surgeon’s view and impede maneuverability of the tool in the area of the posterior perforated substance, which may be addressed using the separation technique, which can lead to positive results. In addition, the medial habenula-interpeduncular nucleus in the posterior perforated substance is associated with various addictions and psychiatric conditions. Conclusions: The posterior perforated substance area is of great interest for surgical interventions. Future studies of the interpeduncular nucleus anticipate the development of drugs to affect different types of dependencies and some mental diseases.

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