Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains

Faculty Opinions recommendation of Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726673095.793523203 ◽

2016 ◽

Author(s):

Robert Peoples

Keyword(s):

Nmda Receptor ◽

Glutamate Receptor ◽

Transmembrane Domain ◽

Allosteric Modulators ◽

Positive Allosteric Modulators ◽

Pore Properties

Molecular modeling of the transmembrane domain of mGluR2 metabotropic glutamate receptor and the binding site of its positive allosteric modulators

Doklady Biochemistry and Biophysics ◽

10.1134/s1607672914010050 ◽

2014 ◽

Vol 454 (1) ◽

pp. 13-16

Author(s):

E. V. Radchenko ◽

D. S. Karlov ◽

V. A. Palyulin ◽

N. S. Zefirov

Keyword(s):

Molecular Modeling ◽

Binding Site ◽

Glutamate Receptor ◽

Transmembrane Domain ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces

Journal of Chemical Information and Modeling ◽

10.1021/ci500559b ◽

2014 ◽

Vol 54 (12) ◽

pp. 3404-3416 ◽

Cited By ~ 14

Author(s):

Ann-Beth Nørholm ◽

Pierre Francotte ◽

Eric Goffin ◽

Iuliana Botez ◽

Laurence Danober ◽

...

Keyword(s):

Ligand Binding ◽

Glutamate Receptor ◽

Computational Methods ◽

Driving Forces ◽

Binding Domain ◽

Ligand Binding Domain ◽

Allosteric Modulators ◽

Thermodynamic Characterization ◽

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

ChemMedChem ◽

10.1002/cmdc.201402190 ◽

2014 ◽

Vol 9 (12) ◽

pp. 2685-2698 ◽

Cited By ~ 1

Author(s):

Xavier Rovira ◽

Youssef Harrak ◽

Ana Trapero ◽

Patricia González-Bulnes ◽

Fanny Malhaire ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Active Conformation ◽

Metabotropic Glutamate ◽

Cyclohexane Carboxylate ◽

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.10.050 ◽

2015 ◽

Vol 25 (24) ◽

pp. 5792-5796 ◽

Cited By ~ 5

Author(s):

John M. Ellard ◽

Andrew Madin ◽

Oliver Philps ◽

Mark Hopkin ◽

Scott Henderson ◽

...

Keyword(s):

Glutamate Receptor ◽

Preclinical Model ◽

Allosteric Modulators ◽

Improve Performance ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01733 ◽

2020 ◽

Vol 63 (14) ◽

pp. 7569-7600

Author(s):

Matthew P. Epplin ◽

Ayush Mohan ◽

Lynnea D. Harris ◽

Zongjian Zhu ◽

Katie L. Strong ◽

...

Keyword(s):

Nmda Receptor ◽

Second Generation ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse?

Biological Psychiatry ◽

10.1016/j.biopsych.2015.07.008 ◽

2015 ◽

Vol 78 (7) ◽

pp. 436-438 ◽

Cited By ~ 1

Author(s):

Kari A. Johnson ◽

David M. Lovinger

Keyword(s):

Drug Abuse ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

Expert Opinion on Therapeutic Patents ◽

10.1517/13543770903045009 ◽

2009 ◽

Vol 19 (9) ◽

pp. 1259-1275 ◽

Cited By ~ 36

Author(s):

Mark E Fraley

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.206623 ◽

2013 ◽

Vol 347 (2) ◽

pp. 438-457 ◽

Cited By ~ 34

Author(s):

K.J. Gregory ◽

E.J. Herman ◽

A.J. Ramsey ◽

A.S. Hammond ◽

N.E. Byun ◽

...

Keyword(s):

Glutamate Receptor ◽

Cognitive Enhancement ◽

Allosteric Modulators ◽

Preclinical Models ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.6b00292 ◽

2016 ◽

Vol 7 (12) ◽

pp. 1082-1086 ◽

Cited By ~ 12

Author(s):

Matthew D. Hill ◽

Haiquan Fang ◽

Jeffrey M. Brown ◽

Thaddeus Molski ◽

Amy Easton ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽