scholarly journals Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor

2020 ◽  
Vol 63 (14) ◽  
pp. 7569-7600
Author(s):  
Matthew P. Epplin ◽  
Ayush Mohan ◽  
Lynnea D. Harris ◽  
Zongjian Zhu ◽  
Katie L. Strong ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Second Generation ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

2016 ◽  
Vol 59 (6) ◽  
pp. 2760-2779 ◽  
Author(s):  
Matthew Volgraf ◽  
Benjamin D. Sellers ◽  
Yu Jiang ◽  
Guosheng Wu ◽  
Cuong Q. Ly ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Allosteric Modulators ◽  
Deactivation Kinetics ◽  
Positive Allosteric Modulators

scholarly journals Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

2012 ◽  
Vol 61 (4) ◽  
pp. 581-592 ◽  
Author(s):  
Daniel T. Monaghan ◽  
Mark W. Irvine ◽  
Blaise Mathias Costa ◽  
Guangyu Fang ◽  
David E. Jane
Keyword(s):  
Nmda Receptor ◽  
Receptor Activity ◽  
Allosteric Modulators ◽  
Pharmacological Modulation ◽  
Positive Allosteric Modulators

scholarly journals The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

2017 ◽  
Vol 93 (2) ◽  
pp. 141-156 ◽  
Author(s):  
Thomas M. Kaiser ◽  
Steven A. Kell ◽  
Hirofumi Kusumoto ◽  
Gil Shaulsky ◽  
Subhrajit Bhattacharya ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators ◽  
Ligand Conformation

scholarly journals Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel

2015 ◽  
Vol 172 (5) ◽  
pp. 1333-1347 ◽  
Author(s):  
Christine M Emnett ◽  
Lawrence N Eisenman ◽  
Jayaram Mohan ◽  
Amanda A Taylor ◽  
James J Doherty ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators ◽  
Nmda Receptor Channel ◽  
Receptor Channel
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