scholarly journals Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development

1988 ◽  
Vol 8 (7) ◽  
pp. 2321-2333 ◽  
Author(s):  
A Nehlig ◽  
AP de Vasconcelos ◽  
S Boyet
1991 ◽  
Vol 205 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Peter Room ◽  
Antoon J.P.C. Tielemans ◽  
Thijs De Boer ◽  
Anton M.L. Van Delft ◽  
Jeroen A.D.M. Tonnaer

Peptides ◽  
2000 ◽  
Vol 21 (11) ◽  
pp. 1751-1753 ◽  
Author(s):  
Francesco E Pontieri ◽  
Maurizia Rasura ◽  
Alessandra Scontrini ◽  
Francesca R Buttarelli

1988 ◽  
Vol 8 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Floyd R. Domer ◽  
Kentaro Mori ◽  
Charles A. Dinarello ◽  
Louis Sokoloff

Changes in body temperature were recorded in freely moving rats given phosphate-buffered saline or leukocytic pyrogen (interleukin-1) while the animals were in an infant incubator maintained at 25.5 ± 0.5°C. The leukocytic pyrogen increased body temperature by at least 1°C within 1 h. This rise in temperature was prevented by premedication with indomethacin (10 mg/kg) but not dexamethasone (0.5 mg/kg) given 15 min before the leukocytic pyrogen. Local rates of glucose utilization were measured in 47 regions of the central nervous system. In none of the regions previously reported to have an increased rate of glucose utilization associated with an ambient temperature of 32.5°C (McCulloch et al., 1982b) was an increase found in the present experiments. It was concluded that the intensity of the changes in local cerebral glucose utilization in response to the fever caused by the leukocytic pyrogen was insufficient to be measured. Neither indomethacin nor dexamethasone caused remarkable changes in rates of local glucose utilization.


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