scholarly journals Role of dynorphin and GABA in the inhibitory regulation of NMDA-induced dopamine release in striosome- and matrix-enriched areas of the rat striatum

1994 ◽  
Vol 14 (4) ◽  
pp. 2435-2443 ◽  
Author(s):  
MO Krebs ◽  
C Gauchy ◽  
M Desban ◽  
J Glowinski ◽  
ML Kemel
2008 ◽  
Vol 193 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Mark R.C. Daglish ◽  
Tim M. Williams ◽  
Sue J. Wilson ◽  
Lindsay G. Taylor ◽  
Chin B. Eap ◽  
...  

BackgroundDrugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugsAimsWe tested whether opioids provoke dopamine release and its relationship to the subjective experienceMethodIn two combined studies 14 heroin addicts on methadone maintenance treatment underwent two positron emission tomography brain scans of the dopamine system using [11C]-raclopride following an injection of placebo and either 50 mg intravenous diamorphine or 10 mg subcutaneous hydromorphone in a double-blind, random order designResultsBoth opioids produced marked subjective and physiological effects, but no measurable change in [11C]-raclopride bindingConclusionsThe absence of a dopamine response to opioid agonists contrasts with that found with stimulant drugs and suggests dopamine may not play the same role in addiction to opioids. This questions the role of dopamine in the subjective experience of heroin in opioid addicts


1993 ◽  
Vol 32 (7) ◽  
pp. 681-688 ◽  
Author(s):  
M. Matsumoto ◽  
M. Inagaki ◽  
Y. Kiuchi ◽  
J. Izumi ◽  
Y. Yamazaki ◽  
...  

1992 ◽  
Vol 17 ◽  
pp. 57
Author(s):  
Takahiko Tanaka ◽  
Masami Yoshida ◽  
Hideyasu Yokoo ◽  
Katsuhiro Mizoguchi ◽  
Masatoshi Tanaka

Toxicology ◽  
2013 ◽  
Vol 311 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Lilian R.F. Faro ◽  
Brenda V. Ferreira Nunes ◽  
Miguel Alfonso ◽  
Vania M. Ferreira ◽  
Rafael Durán

1986 ◽  
Vol 126 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Francis Petit ◽  
Michel Hamon ◽  
Marie-Claude Fournie-Zaluski ◽  
Bernard P. Roques ◽  
Jacques Glowinski

1991 ◽  
Vol 56 (1) ◽  
pp. 81-85 ◽  
Author(s):  
M. O. Krebs ◽  
J. M. Desce ◽  
M. L. Kemel ◽  
C. Gauchy ◽  
G. Godeheu ◽  
...  

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