Reduction of 3H-spiroperidol binding in rat striatum and frontal cortex by chronic amphetamine: Dose response, time course and role of sustained dopamine release

1983 ◽  
Vol 81 (1) ◽  
pp. 81-85 ◽  
Author(s):  
E. B. Nielsen ◽  
M. Nielsen ◽  
C. Braestrup
Keyword(s):  
Response Time ◽  
Frontal Cortex ◽  
Dose Response ◽  
Dopamine Release ◽  
Time Course ◽  
Rat Striatum ◽  
Chronic Amphetamine

scholarly journals Brain dopamine response in human opioid addiction

2008 ◽  
Vol 193 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Mark R.C. Daglish ◽  
Tim M. Williams ◽  
Sue J. Wilson ◽  
Lindsay G. Taylor ◽  
Chin B. Eap ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Subjective Experience ◽  
Methadone Maintenance ◽  
Random Order ◽  
Rat Striatum ◽  
Dopamine System ◽  
Double Blind ◽  
Brain Scans ◽  
Positron Emission

BackgroundDrugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugsAimsWe tested whether opioids provoke dopamine release and its relationship to the subjective experienceMethodIn two combined studies 14 heroin addicts on methadone maintenance treatment underwent two positron emission tomography brain scans of the dopamine system using [11C]-raclopride following an injection of placebo and either 50 mg intravenous diamorphine or 10 mg subcutaneous hydromorphone in a double-blind, random order designResultsBoth opioids produced marked subjective and physiological effects, but no measurable change in [11C]-raclopride bindingConclusionsThe absence of a dopamine response to opioid agonists contrasts with that found with stimulant drugs and suggests dopamine may not play the same role in addiction to opioids. This questions the role of dopamine in the subjective experience of heroin in opioid addicts

Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: dose response, time course and sex differences

2009 ◽  
Vol 26 (7) ◽  
pp. 1070-1080 ◽  
Author(s):  
Xianai Wu ◽  
Marian Kohut ◽  
Joan Cunnick ◽  
Ted Bailey ◽  
Suzanne Hendrich
Keyword(s):  
Sex Differences ◽  
Response Time ◽  
Dose Response ◽  
Time Course

Role of calcium ions in dopamine release induced by sodium cyanide perfusion in rat striatum

1993 ◽  
Vol 32 (7) ◽  
pp. 681-688 ◽  
Author(s):  
M. Matsumoto ◽  
M. Inagaki ◽  
Y. Kiuchi ◽  
J. Izumi ◽  
Y. Yamazaki ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Dopamine Release ◽  
Sodium Cyanide ◽  
Rat Striatum

The role of potassium channel in autoreceptor-regulated dopamine release in the rat striatum: In vivo microdialysis study

1992 ◽  
Vol 17 ◽  
pp. 57
Author(s):  
Takahiko Tanaka ◽  
Masami Yoshida ◽  
Hideyasu Yokoo ◽  
Katsuhiro Mizoguchi ◽  
Masatoshi Tanaka
Keyword(s):  
Potassium Channel ◽  
Dopamine Release ◽  
In Vivo Microdialysis ◽  
Rat Striatum ◽  
Microdialysis Study
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