scholarly journals Active Zone Localization of Presynaptic Calcium Channels Encoded by the cacophony Locus of Drosophila

2004 ◽  
Vol 24 (1) ◽  
pp. 282-285 ◽  
Author(s):  
F. Kawasaki
2006 ◽  
Vol 34 (5) ◽  
pp. 939-941 ◽  
Author(s):  
R.J. Kittel ◽  
S. Hallermann ◽  
S. Thomsen ◽  
C. Wichmann ◽  
S.J. Sigrist ◽  
...  

Neurotransmitter release at chemical synapses occurs when synaptic vesicles fuse to the presynaptic membrane at a specialized site termed the active zone. The depolarization-induced fusion is highly dependent on calcium ions, and, correspondingly, the transmission characteristics of synapses are thought to be influenced by the spatial arrangement of voltage-gated calcium channels with respect to vesicle release sites. Here, we review the involvement of the Drosophila Bruchpilot (BRP) protein in active zone assembly, a process that is required for the clustering of presynaptic calcium channels to ensure efficient vesicle release.


2018 ◽  
Vol 127 ◽  
pp. 33-44 ◽  
Author(s):  
Sumiko Mochida

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