scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Cushing's syndrome: a structured short- and long-term management plan for patients in remission

2013 ◽  
Vol 169 (5) ◽  
pp. R139-R152 ◽  
Author(s):  
Oskar Ragnarsson ◽  
Gudmundur Johannsson

One hundred years have passed since Harvey Williams Cushing presented the first patient with the syndrome that bears his name. In patients with Cushing's syndrome (CS), body composition and lipid, carbohydrate and protein metabolism are dramatically affected and psychopathology and cognitive dysfunction are frequently observed. Untreated patients with CS have a grave prognosis with an estimated 5-year survival of only 50%. Remission can be achieved by surgery, radiotherapy and sometimes with medical therapy. Recent data indicate that the adverse metabolic consequences of CS are present for years after successful treatment. In addition, recent studies have demonstrated that health-related quality of life and cognitive function are impaired in patients with CS in long-term remission. The focus of specialised care should therefore be not only on the diagnostic work-up and the early postoperative management but also on the long-term follow-up. In this paper, we review the long-term consequences in patients with CS in remission with focus on the neuropsychological effects and discuss the importance of these findings for long-term management. We also discuss three different phases in the postoperative management of surgically-treated patients with CS, each phase distinguished by specific challenges: the immediate postoperative phase, the glucocorticoid dose tapering phase and the long-term management. The focus of the long-term specialised care should be to identify cognitive impairments and psychiatric disorders, evaluate cardiovascular risk, follow pituitary function and detect possible recurrence of CS.

Critical Care ◽  
2008 ◽  
Vol 12 (5) ◽  
pp. 429 ◽  
Author(s):  
Christopher J Longo ◽  
Daren K Heyland ◽  
Harold N Fisher ◽  
Robert A Fowler ◽  
Claudio M Martin ◽  
...  

Burns ◽  
2019 ◽  
Vol 45 (6) ◽  
pp. 1300-1310 ◽  
Author(s):  
David Gojowy ◽  
Martin Kauke ◽  
Tobias Ohmann ◽  
Heinz-Herbert Homann ◽  
Lijo Mannil

HemaSphere ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. e336 ◽  
Author(s):  
Nadine Kutsch ◽  
Jasmin Bahlo ◽  
Sandra Robrecht ◽  
Jeremy Franklin ◽  
Can Zhang ◽  
...  

Stroke ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. 2584-2590 ◽  
Author(s):  
Josefine Persson ◽  
Lukas Holmegaard ◽  
Ingvar Karlberg ◽  
Petra Redfors ◽  
Katarina Jood ◽  
...  

Critical Care ◽  
2007 ◽  
Vol 11 (6) ◽  
pp. R128 ◽  
Author(s):  
Christopher J Longo ◽  
Daren K Heyland ◽  
Harold N Fisher ◽  
Robert A Fowler ◽  
Claudio M Martin ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document