scholarly journals Bilirubin-Induced Cerebellar Hypoplasia in Gunn Rats and Sequencing of Bilirubin UDP-Glucuronosyltransferase cDNA.

1991 ◽  
Vol 7 ◽  
pp. 13-18
Author(s):  
Hiroomi KEINO ◽  
Hiroshi SATO ◽  
Shigeo KASHIWAMATA
Keyword(s):  
Cerebellar Hypoplasia ◽  
Gunn Rats ◽  
Udp Glucuronosyltransferase

scholarly journals Mechanism of the lack of induction of UDP-glucuronosyltransferase activity in Gunn rats by 3-methylcholanthrene. Identification of a truncated enzyme.

1990 ◽  
Vol 265 (18) ◽  
pp. 10752-10758
Author(s):  
M elAwady ◽  
J R Chowdhury ◽  
K Kesari ◽  
H van Es ◽  
P L Jansen ◽  
...  
Keyword(s):  
Gunn Rats ◽  
Udp Glucuronosyltransferase

scholarly journals Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities

2009 ◽  
Vol 329 (3) ◽  
pp. 1023-1031 ◽  
Author(s):  
Stephen W. J. Wang ◽  
Kaustubh H. Kulkarni ◽  
Lan Tang ◽  
Jing Rong Wang ◽  
Taijun Yin ◽  
...  
Keyword(s):  
Gunn Rats ◽  
Udp Glucuronosyltransferase

Effect of Donor Strains and Age of the Recipient in the Use of Microencapsulated Hepatocytes to Control Hyperbilirubinemia in the Gunn Rat

1995 ◽  
Vol 18 (6) ◽  
pp. 332-339 ◽  
Author(s):  
S. Bruni ◽  
T.M.S. Chang
Keyword(s):  
Acute Rejection ◽  
Peritoneal Cavity ◽  
Serum Bilirubin ◽  
Critical Factor ◽  
Rat Hepatocytes ◽  
Wistar Rat ◽  
Rat Strains ◽  
Gunn Rats ◽  
Udp Glucuronosyltransferase ◽  
One Year

Hepatocytes of certain rat strains are spontaneously accepted when they are implanted in the peritoneal cavity. Therefore to evaluate if microcapsules are able to immunoisolate the hepatocytes, it is necessary to find the strain of rat whose free hepatocytes are rejected. Hepatocytes were collected from Buffalo rats and were implanted intraperitoneally in one year old Gunn rats. During the first two weeks both groups of Gunn rats which received free and encapsulated hepatocytes showed a reduction in the bilirubin level relative to the control. After 15 days, the bilirubin levels increased in the group which received free hepatocytes. This suggests that an acute rejection had taken place. Bilirubin continued to stay high until the end of the experiment and there was no difference between this group and the control. As the animal ages, there is a significant accumulation of bilirubin in the tissues which affects the net reduction of serum bilirubin since once bilirubin is conjugated by the transplanted hepatocytes and eliminated, some of the bilirubin deposited in the tissues diffuses into the blood preventing a major drop in serum bilirubin levels. The findings that UDP-glucuronosyltransferase (UDPGT) activity of Buffalo rat hepatocytes is the same as the UDPGT activity of Wistar rat hepatocytes, imply that the age of the animal is a very critical factor in determining how great the depression of serum bilirubin will be after implantation of hepatocytes.

scholarly journals Long Term Correction of Bilirubin-UDP-glucuronosyltransferase Deficiency in Gunn Rats by Administration of a Recombinant Adenovirus during the Neonatal Period

1996 ◽  
Vol 271 (43) ◽  
pp. 26536-26542 ◽  
Author(s):  
Minoru Takahashi ◽  
Yaron Ilan ◽  
Namita Roy Chowdhury ◽  
Jack Guida ◽  
Marshall Horwitz ◽  
...  
Keyword(s):  
Neonatal Period ◽  
Recombinant Adenovirus ◽  
Gunn Rats ◽  
Udp Glucuronosyltransferase

Cerebellar hypoplasia and motor development in congenitally jaundiced Gunn rats

1977 ◽  
Vol 18 (2) ◽  
pp. 255-259 ◽  
Author(s):  
Yoshitaka Tamaki ◽  
Reiji Semba ◽  
Sachiko Tooyama
Keyword(s):  
Motor Development ◽  
Cerebellar Hypoplasia ◽  
Gunn Rats

Two proteins associated with cerebellar hypoplasia in jaundiced Gunn rats

1983 ◽  
Vol 8 (6) ◽  
pp. 743-756 ◽  
Author(s):  
Sachiko Aono ◽  
Hiroshi Sato ◽  
Reiji Semba ◽  
Shigeo Kashiwamata
Keyword(s):  
Cerebellar Hypoplasia ◽  
Gunn Rats
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