IVF: fewer complications with single-embryo transfer, but what about the live birth rates?

2010 ◽  
Vol 5 (4) ◽  
pp. 389-391
Author(s):  
Catharina Olivius ◽  
Christina Bergh
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Single Embryo Transfer ◽  
Birth Rates ◽  
Live Birth Rates

Effect of the new legislation and single-embryo transfer policy in Turkey on pregnancy, live birth rates and perinatal outcomes

2012 ◽  
Vol 98 (3) ◽  
pp. S262-S263
Author(s):  
N. Yilmaz ◽  
Y. Ustun ◽  
H. Inal ◽  
U. Gorkem ◽  
Y. Bardakci ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Perinatal Outcomes ◽  
Single Embryo Transfer ◽  
Birth Rates ◽  
Transfer Policy ◽  
Live Birth Rates

scholarly journals Weekend-free scheduled IVF/ICSI procedures and single embryo transfer do not reduce live-birth rates in a general infertile population

2017 ◽  
Vol 96 (12) ◽  
pp. 1423-1429 ◽  
Author(s):  
Michael Feichtinger ◽  
Per O. Karlström ◽  
Jan I. Olofsson ◽  
Kenny A. Rodriguez-Wallberg
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Single Embryo Transfer ◽  
Birth Rates ◽  
Live Birth Rates

scholarly journals 172ELECTIVE SINGLE EMBRYO TRANSFER (ESET) IN HUMANS DOES NOT AFFECT THE CHANCES OF A SUCCESSFUL PREGNANCY

2004 ◽  
Vol 16 (2) ◽  
pp. 208
Author(s):  
J. Catt ◽  
T. Wood ◽  
M. Henman ◽  
R. Jansen
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Live Birth Rate ◽  
Single Embryo Transfer ◽  
Cumulative Live Birth Rate ◽  
Fresh Embryo Transfer ◽  
Birth Rates ◽  
Live Birth Rates ◽  
Cumulative Live Birth ◽  
Transfer Group

Improvements in human IVF have led to increased pregnancy rates but at the expense of increasing twinning rates. Twins are a bad outcome for the offspring, parents and the healthcare system. An obvious solution to this is to transfer only one embryo and freeze the rest for potential further treatment. This study looked at the effect of doing this on the cumulative live birth rate (when the cryopreserved embryos were thawed and transferred). Patients less than 38 years of age presenting for IVF treatment and with more than two embryos suitable for transfer were offered the chance of transferring only one embryo (elective single embryo transfer, eSET) and freezing the rest. Those patients declining a single embryo transfer had two transferred and served as the controls. Patients not achieving a pregnancy returned for a frozen embryo transfer but were not restricted on the number transferred (to a maximum of two). Cumulative live birth rates were recorded over the ensuing two years. Statistical comparisons were made using paired chi-square tests. The live birth rates from the initial fresh transfer was 41% for eSET (41/111) and significantly higher (53%, P<0.05) for the two-embryo transfer group. These differences were eliminated when the frozen embryos were factored in, both groups rising to 61% of patients treated (68 and 172 live births, respectively). The twinning rate was significantly reduced (P<0.01) from 33% in the two-embryo transfer group to 6% (arising from 4 sets of twins in the frozen embryo transfers) in the eSET group. eSET in the fresh embryo transfer cycle does not affect the chances of a live birth and reduces the twinning rate at least fivefold. Currently, 70% of patients under the age of 38 are electing to have eSET.

P–780 The increase of single embryo transfers does not impair pregnancy and live birth rates, although it lowers twin rate

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M Stimpfel ◽  
L Bacer-Kermavner ◽  
T Fevzer ◽  
P Petric ◽  
N Jancar ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Culture Media ◽  
Statistical Significance ◽  
Live Birth Rate ◽  
Single Embryo Transfer ◽  
Favorable Effect ◽  
Birth Rates ◽  
Live Birth Rates

Abstract Study question How does significant increase of the proportion of single embryo transfer over 10 years period affect pregnancy, live birth and twin rate. Summary answer Increase in single embryo transfer doesn’t change pregnancy and live birth rate, although it significantly lowers twin rate. What is known already Due to widely used approach in IVF of transferring multiple embryos to improve the pregnancy and birth rate, multiple pregnancies, mostly twin, are quite common. But because they are more often associated with adverse neonatal and perinatal outcomes as singleton pregnancies, they are not desirable. Therefore, more and more often the transfer of single embryo is encouraged. Furthermore, in the last years with improvements in cryopreservation techniques leading to effective cryopreservation of supernumerary embryos, there is more options for performing repeated single embryo transfers. Study design, size, duration We retrospectively collected the data of all fresh embryo transfers in couples treated in our centre from January 2010 to December 2019. We excluded embryo transfer where embryos were derived from cryopreserved oocytes and analysed the outcome of fresh embryo transfer regarding to the number of transferred embryos. Participants/materials, setting, methods In our analysis we included 10583 fresh embryo transfers. We tried to evaluate how the proportion of single embryo transfer has changed through analysed period of time and if this led to any differences in pregnancy, live birth, and twin rate. To determine the differences between the groups, the data were analysed with one-way ANOVA and Pearson’s chi-square, as appropriate. Statistical significance was set at P < 0.05. Main results and the role of chance The analysis revealed that the proportion of single embryo transfers significantly increased from year 2010 to year 2019 (from 28% to 73%; P < 0.001). The proportion increased every year, minimum increase was 1% whereas maximum increase was 16%. This increase over the years did not negatively affect the pregnancy (32% in 2010 vs. 34% in 2019: p = 0.317) and live birth rates (24% vs. 25%; p = 0.584), although it had favorable effect on twin rate (16% vs. 7%; p = 0.002). If we separately analyzed only single and double embryo transfer, we observed that pregnancy (24% in 2010 and 34% in 2019; p = 0.001) and live birth rates (17% vs. 26%, p = 0.001) significantly increased after single embryo transfers, but no difference was observed in double embryo transfers (pregnancy rate: 35% vs. 35%, p = 1; live birth rate: 27% vs. 22%, p = 0.097; twins rate: 20% vs. 27%, p = 0.244). Additionally, we observed that female mean age value significantly increased over analyzed period (34.2±4.5 years in 2010 vs. 35.7±4.7 years in 2019, p < 0.001), although there was no difference in mean number of retrieved oocytes (8.2±5.4 vs. 8.1±4.9, p = 1) and obtained embryos (4.5±3.3 vs. 4.2±2.9; p = 0.684). Limitations, reasons for caution The limitation of the study is retrospective design, and not evaluating the influence of elective single embryo transfer. Also, the IVF laboratory methods and IVF culture media improved over the years meaning they could be partly responsible for observed differences. Wider implications of the findings: Single embryo transfer could probably be performed in even higher proportion without lowering the chances for pregnancy. Trial registration number not applicable’

Elective single embryo transfer in women less than age 38 years reduces multiple birth rates, but not live birth rates, in United States fertility clinics

2016 ◽  
Vol 106 (5) ◽  
pp. 1107-1114 ◽  
Author(s):  
Abigail C. Mancuso ◽  
Sheree L. Boulet ◽  
Eyup Duran ◽  
Erika Munch ◽  
Dmitry M. Kissin ◽  
...  
Keyword(s):  
United States ◽  
Embryo Transfer ◽  
Live Birth ◽  
Single Embryo Transfer ◽  
Multiple Birth ◽  
Birth Rates ◽  
Elective Single Embryo Transfer ◽  
Live Birth Rates

Effect of uterine dimensions on live birth rates after single embryo transfer in infertile women

2020 ◽  
Vol 41 (4) ◽  
pp. 663-670
Author(s):  
Naama Steiner ◽  
Senem Ates ◽  
Talya Shaulov ◽  
Samer Tannus ◽  
Michael H. Dahan
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Single Embryo Transfer ◽  
Birth Rates ◽  
Infertile Women ◽  
Live Birth Rates
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