Chronic hepatitis B virus infection is a major cause of cirrhosis and hepatocellular carcinomaworldwide. Antiviral treatment can safely and effectively suppress viral replication and reduce riskof disease progression but need long term therapy. However, understanding the natural history ofhepatitis B virus infection is important when deciding whether to treat or not to treat the patients.On the basis of virus-host interaction, the natural course of HBV infection can be divided into four phases.The elevation of alanine aminotransferase (ALT) level is an important indicator of immune-mediatedinflammation to eliminate HBV infected hepatocyte. The individual patients with normal ALTare assume to be the immune tolerance phase and low risk to disease progression.
Figure 1 ระยะของการติดเชื้อไวรัสตับอักเสบบีชนิดเรื้อรัง
Keywords: chronic hepatitis B, HBV, ALT
Serum microRNA-30c levels are correlated with disease progression in Xinjiang Uygur patients with chronic hepatitis B
