scholarly journals GAMMA GLUTAMYLTRANSFERASE IMPACT IN THERAPEUTIC RESPONSE OF CHRONIC HEPATITIS C: a systematic review of the literature

2015 ◽  
Vol 52 (3) ◽  
pp. 239-246
Author(s):  
Maria de Lourdes Albuquerque de QUEIROGA ◽  
Raymundo PARANÁ ◽  
José Eymard Moraes de MEDEIROS FILHO ◽  
Giovannini Cesar A FIGUEIREDO ◽  
Ananda Peixoto de ARAÚJO ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Sustained Virologic Response ◽  
Pegylated Interferon ◽  
Virologic Response ◽  
Early Virological Response ◽  
Gamma Glutamyltransferase ◽  
Interferon Α2a

BackgroundThe standard treatment of chronic hepatitis C is the administration of pegylated interferon α2a or α2b in combination with ribavirin, but adverse effects can be observed, as well as the high cost of this therapy. Therefore, there is interest in understanding the predictors of sustained virologic response, as the gamma glutamyltransferase.ObjectiveTo evaluate the serum levels of gamma glutamyltransferase as a predictor of response to treatment with pegylated interferon α and ribavirin in chronic hepatitis C.MethodsThis is a systematic review of literature, conducted by consulting PUBMED, LILACS, MEDLINE, SCOPUS, Cochrane electronic databases, and active search of articles selected between January 2000 and April 2013.ResultsA total of 4,785 titles were iden tified. Out of those material, following inclusion and exclusion criteria, 273 abstracts were selected, by two independent researchers. After reading those texts, the reviewers consensually included ten studies for systematization and classification, according to the criteria of the Oxford Scale. 1B studies are predominant (prospective cohort study - six studies). Rapid virologic response and early virological response were considered as estimates for the sustained virological response. The frequency of virologic response was identified in three studies and early virological response in two, with a total of 392 and 413 patients, respectively; sustained virologic response was reported in nine articles corresponding to 3,787 patients (76.5 %).ConclusionGamma glutamyltransferase is a predictor of sustained virologic response in the treatment of chronic hepatitis C with pegylated interferon α2a or α2b associated with ribavirin.

Early Virological Response in Children with Chronic Hepatitis C Treated with Pegylated Interferon and Ribavirin

Infection ◽  
2007 ◽  
Vol 35 (3) ◽  
pp. 175-179 ◽  
Author(s):  
A. Kowala-Piaskowska ◽  
W. Służewski ◽  
M. Figlerowicz ◽  
I. Mozer-Lisewska
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Pegylated Interferon ◽  
Early Virological Response

scholarly journals Clinical features of chronic hepatitis C and efficacy of antiviral treatment in Caucasian and Mongoloid patients

2015 ◽  
Vol 96 (1) ◽  
pp. 27-32
Author(s):  
S I Malov ◽  
B Dulguun ◽  
I V Malov ◽  
L A Stepanenko ◽  
I A Miroshnichenko ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Antiviral Treatment ◽  
Pegylated Interferon ◽  
Virologic Response ◽  
Chronic Viral Hepatitis ◽  
Interleukin 28B ◽  
Caucasian Patients

Aim. To present the comparative clinical characteristics of chronic hepatitis C infection and to estimate the effect of antiviral treatment in Caucasian and Mongoloid patients, considering interleukin-28B gene polymorphism in study populations.Methods. Population and genetic study including 1520 healthy subjects and 267 patients with chronic viral hepatitis of Caucasian and Mongoloid race analyzed interleukin-28B gene polymorphism. 433 patients with chronic viral hepatitis C were followed up. Combined antiviral treatment by pegylated interferon alfa-2a and ribavirin was administered for 48 weeks. The rates of early and sustained virologic response were the endpoints for assessing antiviral treatment effect. 82 Caucasian patients and 42 Mongoloid patients have completed the full course of antiviral treatment and 24 weeks of follow-up.Results. The following clinical features of chronic hepatitis C were revealed in Mongoloids: more extensive liver fibrosis, older age, longer infection duration and higher total cholesterol levels (due to triglycerides). These factors negate the expected better effect of antiviral therapy effect, associated with higher prevalence of interleukin-28B favorable genotypes in Mongolian population. The presence of the C-allele of rs12979860 gene and T-allele of rs8099917 gene reaches 89.6 and 91.7% respectively in Mongolian population, which is comparable with those in China, Japan and Korea, and is typical for the whole of Asia. Combined treatment with pegylated interferon alfa-2a and ribavirin in patients with genotype 1 of hepatitis C virus led to sustained virologic response in 78.5% of Mongoloid and in 56.1% of Caucasian patients; groups were totally comparable.Conclusion. Mongoloid patients with chronic hepatitis C reached sustained virologic response to antiviral treatment with pegylated interferon and ribavirin significantly more frequently compared to Caucasians, in cases of no aggravating factors and minimal liver fibrosis.

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