Effect of Long-term Tacrolimus Immunosuppression on Renal Function in Liver Transplant Recipients

2006 ◽  
Vol 26 (10) ◽  
pp. 1433-1437 ◽  
Author(s):  
Shelby L Corman ◽  
Kim C Coley ◽  
Kristine S Schonder
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

LONG-TERM EFFECTS OF CYCLOSPORINS ON RENAL FUNCTION IN LIVER TRANSPLANT RECIPIENTS

1987 ◽  
Vol 43 (5) ◽  
pp. 641-646 ◽  
Author(s):  
H. C. WHEATLEY ◽  
MARYLIN DATZMAN ◽  
JAMES W. WILLIAMS ◽  
DON E. MILES ◽  
FRED E. HATCH
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Long Term Effects ◽  
Liver Transplant Recipients

BK VIRUS INFECTION/REPLICATION PREVALENCE IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS AND ITS RELATION TO LONG TERM RENAL FUNCTION LOSS

2010 ◽  
Vol 90 ◽  
pp. 433
Author(s):  
G. VARELA-FASCINETTO ◽  
B. RUSSEK-PORTALES ◽  
M. MEDEIROS-DOMINGO ◽  
J. A. HERNANDEZ-PLATA ◽  
P. GARCIA-ROCA
Keyword(s):  
Renal Function ◽  
Virus Infection ◽  
Liver Transplant ◽  
Bk Virus ◽  
Transplant Recipients ◽  
Pediatric Liver ◽  
Function Loss ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant

Systemic hypertension and renal function in long-term liver transplant recipients on cyclosporine

2000 ◽  
Vol 32 (2) ◽  
pp. 449-452 ◽  
Author(s):  
S Semhoun-Ducloux ◽  
D Ducloux ◽  
S Bresson-Hadni ◽  
M.-C Becker ◽  
C Vanlemmens ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Systemic Hypertension ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals The effect of early everolimus administration on the renal function while reducing the dosage of calcineurin inhibitors in liver transplant recipients in a long-term follow-up

2021 ◽  
Vol 13 (2) ◽  
pp. 121-129
Author(s):  
V. E. Syutkin ◽  
A. A. Salienko ◽  
O. D. Olisov ◽  
S. V. Zhuravel ◽  
M. S. Novruzbekov
Keyword(s):  
Liver Transplantation ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Liver Transplant ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Introduction. The lifelong use of calcineurin inhibitors in liver transplant recipients leads to an increased incidence of chronic kidney disease.Objective. To compare the changes in glomerular filtration rate over five years in liver transplant recipients between those on everolimus with a reduced exposure to calcineurin inhibitors and those on standard doses of calcineurin inhibitors.Material and methods. Fourteen liver transplant recipient switched to everolimus with a minimization of calcineurin inhibitors exposure in the first months after liver transplantation from February 2009 to February 2015 who had received that therapy continuously for at least 60 months were included in the case-control study. Twenty eight liver transplant recipients (matched by sex, etiology of the underlying disease, calcineurin inhibitors) who were followed-up for at least 60 months after liver transplantation, who had received no dose of everolimus, in whom the glomerular filtration rate could be calculated at all points of analysis were selected as a comparison group (1:2). Glomerular filtration rate was calculated immediately before liver transplantation; 12, 24, 36, 48, and 60 months after liver transplantation. The glomerular filtration rate after liver transplantation was also calculated for liver transplant recipients from the main group immediately before the conversion to everolimus.Results. Before liver transplantation, the median of glomerular filtration rate in the main group of liver transplant recipients was lower (81.2 ml/min) than in the comparison group (97.5 ml/min, p=0.01). After liver transplantation, the renal function worsened in both groups of patients. In a pairwise comparison, the medians of glomerular filtration rate were statistically significantly lower after 12 months, 24 months, 36 months, 48 months after liver transplantation, than before liver transplantation. The median of glomerular filtration rate at the time of immunosuppression conversion was 44.3 ml/min. After the conversion of immunosuppression, the median of glomerular filtration rate gradually increased, and after 36 months the differences in glomerular filtration rate reached statistical significance compared with the level before conversion (69.4 ml/min;p=0.048). These differences still increased after 60 months after conversion (72.3 ml/min; p=0.041).Conclusion. Long-term administration of everolimus with minimization of calcineurin inhibitors exposure with the early conversion to this immunosuppression regime provides a steady improvement in renal function in liver transplant recipients with a low glomerular filtration rate in the preoperative and early post-transplant period.

Long-term renal function in liver transplant recipients and impact of immunosuppressive regimens (calcineurin inhibitors alone or in combination with mycophenolate mofetil): The TRY study

2009 ◽  
Vol 15 (9) ◽  
pp. 1083-1091 ◽  
Author(s):  
Svetlana Karie-Guigues ◽  
Nicolas Janus ◽  
Faouzi Saliba ◽  
Jerome Dumortier ◽  
Christophe Duvoux ◽  
...  
Keyword(s):  
Renal Function ◽  
Mycophenolate Mofetil ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Long-Term Renal Function in Liver Transplant Recipients After Conversion From Calcineurin Inhibitors to mTOR Inhibitors

2015 ◽  
Vol 20 ◽  
pp. 707-713 ◽  
Author(s):  
Anna Hüsing ◽  
Martina Schmidt ◽  
Susanne Beckebaum ◽  
Vito R. Cicinnati ◽  
Raphael Koch ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Mtor Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Peritoneal Dialysis After Liver Transplantation: A Systematic Review

2021 ◽  
Vol 8 ◽  
pp. 205435812110297
Author(s):  
Jean Maxime Côté ◽  
Isabelle Ethier ◽  
Héloïse Cardinal ◽  
Marie-Noëlle Pépin
Keyword(s):  
Systematic Review ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Kidney Failure ◽  
Liver Graft ◽  
Transplant Recipients ◽  
Technique Survival ◽  
Liver Transplant Recipients

Background: Chronic kidney disease following liver transplantation is a major long-term complication. Most liver transplant recipients with kidney failure will be treated with dialysis instead of kidney transplantation due to noneligibility and shortage in organ availability. In this population, the role of peritoneal dialysis (PD) as a modality of kidney replacement therapy (KRT) remains unclear. Objective: To determine the feasibility regarding safety, technique survival, and dialysis efficiency of PD in liver transplant recipients requiring KRT for maintenance dialysis. Design: Systematic review. Setting: Interventional and observational studies reporting the use of PD after liver transplantation. Patients: Adult liver transplant recipients with kidney failure treated with maintenance KRT. Measurements: Extracted data included eligibility criteria, study design, demographics, and PD modality. The following outcomes of interest were extracted: rate of peritonitis and microorganisms involved, noninfectious peritoneal complications, technique survival, and kidney transplantation-censored technique survival. Non-PD complications included overall survival, liver graft dysfunction, and hospitalization rate. Methods: The following databases were searched until July 2020: MedLine/PubMed, EMBASE, CINAHL, and Cochrane Library. Two reviewers independently screening all titles and abstracts of all identified articles. Due to the limited sample size, observational designs and study heterogeneity expected, no meta-analysis was pre-planned. Descriptive statistics were used to report all results. Results: From the 5263 identified studies, 4 were included in the analysis as they reported at least 1 outcome of interest on a total of 21 liver transplant recipients, with an overall follow-up duration on PD of 19.0 (Interquartile range [IQR]: 9.5-29.5) months. Fifteen episodes of peritonitis occurred in a total cumulative PD follow-up of 514 patient-months, representing an incidence rate of 0.35 per year. These episodes did not result in PD technique failure, mortality, or impairment of liver graft function. Limitations: Limitations include the paucity of studies in the field and the small number of patients included in each report, a risk of publication bias and the impossibility to directly compare hemodialysis to PD in this population. These results, therefore, must be interpreted with caution. Conclusions: Based on limited data reporting the feasibility of PD in liver transplant recipients with kidney failure, no signal was associated with an increased risk of infectious complications. Long-term studies evaluating this modality need to be performed. Registration (PROSPERO): CRD42020218374.

Non-HLA Autoantibodies at 1 Year Negatively Affect 5-Year Native Renal Function in Liver Transplant Recipients

2021 ◽  
Vol 53 (3) ◽  
pp. 1019-1024
Author(s):  
Jacqueline G. O’Leary ◽  
Aurélie Philippe ◽  
Robert Freeman ◽  
Harald Heidecke ◽  
Linda W. Jennings ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Liver Transplant Recipients
Sign in / Sign up

Export Citation Format

Share Document