scholarly journals Histone Modifications and DNA Double-Strand Break Repair after Exposure to Ionizing Radiations

2013 ◽  
Vol 179 (4) ◽  
pp. 383-392 ◽  
Author(s):  
Clayton R. Hunt ◽  
Deepti Ramnarain ◽  
Nobuo Horikoshi ◽  
Puneeth Iyengar ◽  
Raj K. Pandita ◽  
...  
Keyword(s):  
Histone Modifications ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair ◽  
Ionizing Radiations

Histone modifications and DNA double-strand break repair

2004 ◽  
Vol 82 (4) ◽  
pp. 446-452 ◽  
Author(s):  
John D Moore ◽  
Jocelyn E Krebs
Keyword(s):  
Histone Modification ◽  
Histone Modifications ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Homologous Sequence ◽  
Dna Double Strand Break ◽  
Recombination Repair ◽  
Break Repair ◽  
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The roles of different histone modifications have been explored extensively in a number of nuclear processes, particularly in transcriptional regulation. Only recently has the role of histone modification in signaling or facilitating DNA repair begun to be elucidated. DNA broken along both strands in the same region, a double-strand break, is damaged in the most severe way possible and can be the most difficult type of damage to repair accurately. To successfully repair the double-strand break, the cell must gain access to the damaged ends of the DNA and recruit repair factors, and in the case of homologous recombination repair, the cell must also find, colocalize, and gain access to a suitable homologous sequence. In the repair of a double-strand break, the cell must also choose between homologous and non-homologous pathways of repair. Here, we will briefly review the mechanisms of double-strand-break repair, and discuss the known roles of histone modifications in signaling and repairing double-strand breaks.Key words: H23A, double strand break repair, histone modification.

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